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Target
Proteinase-activated receptor 1
Ligand
BDBM150320
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
15.4±n/a nM
Comments
extracted
Citation
 Jeske, M; Heimbach, D; Röhrig, S; Cancho Grande, Y; Schneider, D; Rester, U; Bender, E; Meininghaus, M; Zimmermann, K; Zubov, D; Buchmüller, A; Von Degenfeld, G; Gerdes, C; Gerisch, M; Gnoth, MJ; Gericke, KM Substituted piperidines as Par-1 antagonists US Patent  US8987248 Publication Date 3/24/2015 
Target
Name:
Proteinase-activated receptor 1
Synonyms:
CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1)
Type:
Protein
Mol. Mass.:
47450.07
Organism:
Homo sapiens (Human)
Description:
P25116
Residue:
425
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
  
Inhibitor
Name:
BDBM150320
Synonyms:
US8987248, 134
Type:
Small organic molecule
Emp. Form.:
C24H26F3N3O4S
Mol. Mass.:
509.541
SMILES:
FC(F)(F)c1ccc(cc1)C1CC(CN(C1)C(=O)N1CCS(=O)(=O)CC1)NC(=O)c1ccccc1
Structure:
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