Reaction Details Report a problem with these data
Target
Acetylpolyamine amidohydrolase
Ligand
BDBM152730
Substrate
n/a
Meas. Tech.
APAH Fluorimetric Assay
pH
8.2000±n/a
IC50
68± 6 nM
Comments
extracted
Citation
 Decroos, C; Christianson, DW Design, Synthesis, and Evaluation of Polyamine Deacetylase Inhibitors, and High-Resolution Crystal Structures of Their Complexes with Acetylpolyamine Amidohydrolase. Biochemistry 54:4692-703 (2015) [PubMed]  Article 
Target
Name:
Acetylpolyamine amidohydrolase
Synonyms:
Acetylpolyamine aminohydrolase | APAH_MYCRA | aphA | aph | Acetylpolyamine amidohydrolase (APAH)
Type:
Protein
Mol. Mass.:
36324.64
Organism:
Mycoplana ramosa (Gram-negative bacterium)
Description:
n/a
Residue:
341
Sequence:
MRVIFSEDHKLRNAKTELYGGELVPPFEAPFRAEWILAAVKEAGFDDVVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAIDGADLIAAGHKAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDKGAKKIAILDVDFHHGNGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPLLVVMEGGYGVPEIGLNVANVLKGVAG
  
Inhibitor
Name:
BDBM152730
Synonyms:
7-Amino-N-hydroxypentanamide (6)
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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