Reaction Details
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Platelet-activating factor acetylhydrolase IB subunit alpha2
Ligand
BDBM154534
Substrate
n/a
Meas. Tech.
Competitive ABPP Assays in Proteomes with FP-alkyne
pH
7.5±n/a
IC50
1.4e+3±n/a nM
Comments
extracted
Citation
Chang, JW; Zuhl, AM; Speers, AE; Niessen, S; Brown, SJ; Mulvihill, MM; Fan, YC; Spicer, TP; Southern, M; Scampavia, L; Fernandez-Vega, V; Dix, MM; Cameron, MD; Hodder, PS; Rosen, H; Nomura, DK; Kwon, O; Hsu, KL; Cravatt, BF Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival. ACS Chem Biol 10:925-32 (2015) [PubMed] Article More Info.:
Target
Name:
Platelet-activating factor acetylhydrolase IB subunit alpha2
Synonyms:
PA1B2_MOUSE | Pafah1b2 | Pafahb | Platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2)
Type:
Protein
Mol. Mass.:
25577.50
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
229
Sequence:
MSQGDSNPAAIPHAAEDIQGDDRWMSQHNRFVLDCKDKEPDVLFVGDSMVQLMQQYEIWRELFSPLHALNFGIGGDTTRHVLWRLKNGELENIKPKVIVVWVGTNNHENTAEEVAGGIEAIVQLINTRQPQAKIIVLGLLPRGEKPNPLRQKNAKVNQLLKVSLPKLANVQLLDIDGGFVHSDGAISCHDMFDFLHLTGGGYAKICKPLHELIMQLLEETPEEKQTTIA
Inhibitor
Name:
BDBM154534
Synonyms:
2-(4-bromophenyl)-6-(3,4-dichlorophenyl)-1-(4-methylbenzenesulfonyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid (K9)
Type:
Small organic molecule
Emp. Form.:
C25H20BrCl2NO4S
Mol. Mass.:
581.306
SMILES:
Cc1ccc(cc1)S(=O)(=O)N1C(CC=C(C1c1ccc(Br)cc1)C(O)=O)c1ccc(Cl)c(Cl)c1 |c:14|
Structure:
