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Found 34 with Last Name = 'speers' and Initial = 'ae'
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM119872(3‐(2‐ethoxypropyl)‐2‐sulfa...)
Affinity DataKi:  413nMpH: 7.4Assay Description:Assay mixtures (100 µL) contained 50 mM NaPi (pH 7.4), 150 mM NaCl, 1 mM DTPA, 2% DMSO, the indicated concentrations of H2O2, and Amplex Red. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM119874(3‐[(2S)‐2‐ethoxypropyl]‐2&...)
Affinity DataKi:  429nMpH: 7.4Assay Description:Assay mixtures (100 µL) contained 50 mM NaPi (pH 7.4), 150 mM NaCl, 1 mM DTPA, 2% DMSO, the indicated concentrations of H2O2, and Amplex Red. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM119873(3‐[(2R)‐2‐ethoxypropyl]‐2&...)
Affinity DataKi:  546nMpH: 7.4Assay Description:Assay mixtures (100 µL) contained 50 mM NaPi (pH 7.4), 150 mM NaCl, 1 mM DTPA, 2% DMSO, the indicated concentrations of H2O2, and Amplex Red. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase methylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM75707((3R)-3-cyclopentyl-4-keto-3-phenyl-diazetidine-1,2...)
Affinity DataIC50:  10nMAssay Description:Inhibition of PME1 binding to FP-rhodamine in human MDA-MB-231 cells after 30 mins by fluorescence polarization activity-based protein profiling assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase methylesterase 1(Mus musculus)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50400986(CHEMBL1550905)
Affinity DataIC50:  600nMAssay Description:Inhibition of PME1 binding to FP-rhodamine in mouse brain soluble proteome after 45 mins by fluorescence polarization activity-based protein profilin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase methylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50400986(CHEMBL1550905)
Affinity DataIC50:  600nMAssay Description:Inhibition of PME1 binding to FP-rhodamine in human HEK293T cells after 45 mins by fluorescence polarization activity-based protein profiling assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase methylesterase 1(Mus musculus)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50400987(CHEMBL1316687)
Affinity DataIC50:  640nMAssay Description:Inhibition of PME1 binding to FP-rhodamine in mouse brain soluble proteome after 45 mins by fluorescence polarization activity-based protein profilin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase IB subunit alpha2(Mus musculus (Mouse))
University of California Berkeley

LigandPNGBDBM154536(2-(4-tert-butylphenyl)-1-(4-methylbenzenesulfonyl)...)
Affinity DataIC50:  800nMpH: 7.5Assay Description:For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase IB subunit alpha2(Mus musculus (Mouse))
University of California Berkeley

LigandPNGBDBM154531(2-(4-bromophenyl)-6-(4-chlorophenyl)-1-(4-methylbe...)
Affinity DataIC50:  1.10E+3nMpH: 7.5Assay Description:For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase IB subunit alpha2(Mus musculus (Mouse))
University of California Berkeley

LigandPNGBDBM154529(2-(4-fluorophenyl)-1-(4-methylbenzenesulfonyl)-6-[...)
Affinity DataIC50:  1.10E+3nMpH: 7.5Assay Description:For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase IB subunit alpha2(Mus musculus (Mouse))
University of California Berkeley

LigandPNGBDBM154534(2-(4-bromophenyl)-6-(3,4-dichlorophenyl)-1-(4-meth...)
Affinity DataIC50:  1.40E+3nMpH: 7.5Assay Description:For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase IB subunit alpha2(Mus musculus (Mouse))
University of California Berkeley

LigandPNGBDBM154540(2-(4-(tert-butyl)phenyl)-N-(2-methoxyethyl)-6-(p-t...)
Affinity DataIC50:  1.70E+3nMpH: 7.5Assay Description:For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase IB subunit alpha2(Mus musculus (Mouse))
University of California Berkeley

LigandPNGBDBM154535(2-(4-fluorophenyl)-1-(4-methylbenzenesulfonyl)-6-(...)
Affinity DataIC50:  2.00E+3nMpH: 7.5Assay Description:For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase methylesterase 1(Mus musculus)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50400996(CHEMBL1699083)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of PME1 binding to FP-rhodamine in mouse brain soluble proteome after 45 mins by fluorescence polarization activity-based protein profilin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase methylesterase 1(Mus musculus)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50400995(CHEMBL1706554)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of PME1 binding to FP-rhodamine in mouse brain soluble proteome after 45 mins by fluorescence polarization activity-based protein profilin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase methylesterase 1(Mus musculus)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50400994(CHEMBL1719837)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of PME1 binding to FP-rhodamine in mouse brain soluble proteome after 45 mins by fluorescence polarization activity-based protein profilin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase methylesterase 1(Mus musculus)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50400988(CHEMBL1701914)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of PME1 binding to FP-rhodamine in mouse brain soluble proteome after 45 mins by fluorescence polarization activity-based protein profilin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase methylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50400986(CHEMBL1550905)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of PME1 binding to FP-rhodamine in HEK293T cells after 1 hr by fluorescence polarization activity-based protein profiling assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase methylesterase 1(Mus musculus)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50400993(CHEMBL1729870)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of PME1 binding to FP-rhodamine in mouse brain soluble proteome after 45 mins by fluorescence polarization activity-based protein profilin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase IB subunit alpha2(Mus musculus (Mouse))
University of California Berkeley

LigandPNGBDBM154530(1-(4-methylbenzenesulfonyl)-2-(4-methylphenyl)-6-[...)
Affinity DataIC50:  4.50E+3nMpH: 7.5Assay Description:For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase IB subunit alpha2(Mus musculus (Mouse))
University of California Berkeley

LigandPNGBDBM154542(5-(bromomethyl)-6-(4-(tert-butyl)phenyl)-2-(p-toly...)
Affinity DataIC50:  4.60E+3nMpH: 7.5Assay Description:For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase methylesterase 1(Mus musculus)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50400989(CHEMBL1718102)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of PME1 binding to FP-rhodamine in mouse brain soluble proteome after 45 mins by fluorescence polarization activity-based protein profilin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase methylesterase 1(Mus musculus)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50400991(CHEMBL1711185)
Affinity DataIC50:  6.80E+3nMAssay Description:Inhibition of PME1 binding to FP-rhodamine in mouse brain soluble proteome after 45 mins by fluorescence polarization activity-based protein profilin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase IB subunit alpha2(Mus musculus (Mouse))
University of California Berkeley

LigandPNGBDBM154541(N-allyl-2-(4-(tert-butyl)phenyl)-6-(p-tolyl)-1-tos...)
Affinity DataIC50:  7.50E+3nMpH: 7.5Assay Description:For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase IB subunit alpha2(Mus musculus (Mouse))
University of California Berkeley

LigandPNGBDBM154543(N-((2-(4-(tert-butyl)phenyl)-6-(p-tolyl)-1-tosyl-1...)
Affinity DataIC50:  7.60E+3nMpH: 7.5Assay Description:For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase IB subunit alpha2(Mus musculus (Mouse))
University of California Berkeley

LigandPNGBDBM154533(2-(3-chlorophenyl)-1-(4-methylbenzenesulfonyl)-6-(...)
Affinity DataIC50:  8.20E+3nMpH: 7.5Assay Description:For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase IB subunit alpha2(Mus musculus (Mouse))
University of California Berkeley

LigandPNGBDBM154538(2-(4-(tert-butyl)phenyl)-N-cyclopropyl-6-(p-tolyl)...)
Affinity DataIC50:  9.30E+3nMpH: 7.5Assay Description:For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase IB subunit alpha2(Mus musculus (Mouse))
University of California Berkeley

LigandPNGBDBM154532(2-(3-chlorophenyl)-6-(4-ethylphenyl)-1-(4-methylbe...)
Affinity DataIC50:  9.40E+3nMpH: 7.5Assay Description:For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase IB subunit alpha2(Mus musculus (Mouse))
University of California Berkeley

LigandPNGBDBM154537(2-(4-(tert-butyl)phenyl)-N-methyl-6-(p-tolyl)-1-to...)
Affinity DataIC50: >1.00E+4nMpH: 7.5Assay Description:For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase IB subunit alpha2(Mus musculus (Mouse))
University of California Berkeley

LigandPNGBDBM154544(Methyl-2-(4-(tert-butyl)phenyl)-6-(p-tolyl)-1-tosy...)
Affinity DataIC50: >1.00E+4nMpH: 7.5Assay Description:For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase IB subunit alpha2(Mus musculus (Mouse))
University of California Berkeley

LigandPNGBDBM154539(2-(4-(tert-butyl)phenyl)-N-cyclohexyl-6-(p-tolyl)-...)
Affinity DataIC50: >1.00E+4nMpH: 7.5Assay Description:For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase methylesterase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50400997(CHEMBL1521288)
Affinity DataIC50:  1.08E+4nMAssay Description:Inhibition of PME1 binding to FP-rhodamine in human MDA-MB-231 cells after 30 mins by fluorescence polarization activity-based protein profiling assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase methylesterase 1(Mus musculus)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50400990(CHEMBL1723004)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of PME1 binding to FP-rhodamine in mouse brain soluble proteome after 45 mins by fluorescence polarization activity-based protein profilin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase methylesterase 1(Mus musculus)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50400992(CHEMBL1701983)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of PME1 binding to FP-rhodamine in mouse brain soluble proteome after 45 mins by fluorescence polarization activity-based protein profilin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed