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Target
Oligo-1,6-glucosidase IMA1
Ligand
BDBM175322
Substrate
n/a
Meas. Tech.
Baker's Yeast α-Glucosidase Inhibition Assay
pH
6.8±n/a
IC50
3.453e+4± 2.1e+2 nM
Comments
extracted
Citation
 Zawawi, NK; Taha, M; Ahmat, N; Wadood, A; Ismail, NH; Rahim, F; Azam, SS; Abdullah, N Benzimidazole derivatives as new a-glucosidase inhibitors and in silico studies. Bioorg Chem 64:29-36 (2016) [PubMed]  Article 
Target
Name:
Oligo-1,6-glucosidase IMA1
Synonyms:
α-glucosidase | Alpha-glucosidase | Alpha-glucosidase (α-glucosidase) | IMA1 | MALX3_YEAST | Oligo-1,6-glucosidase
Type:
Protein
Mol. Mass.:
68577.59
Organism:
Saccharomyces cerevisiae S288c (Baker's yeast)
Description:
n/a
Residue:
589
Sequence:
MTISSAHPETEPKWWKEATFYQIYPASFKDSNDDGWGDMKGIASKLEYIKELGADAIWISPFYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSYFGGSAWTFDEKTQEFYLRLFCSTQPDLNWENEDCRKAIYESAVGYWLDHGVDGFRIDVGSLYSKVVGLPDAPVVDKNSTWQSSDPYTLNGPRIHEFHQEMNQFIRNRVKDGREIMTVGEMQHASDETKRLYTSASRHELSELFNFSHTDVGTSPLFRYNLVPFELKDWKIALAELFRYINGTDCWSTIYLENHDQPRSITRFGDDSPKNRVISGKLLSVLLSALTGTLYVYQGQELGQINFKNWPVEKYEDVEIRNNYNAIKEEHGENSEEMKKFLEAIALISRDHARTPMQWSREEPNAGFSGPSAKPWFYLNDSFREGINVEDEIKDPNSVLNFWKEALKFRKAHKDITVYGYDFEFIDLDNKKLFSFTKKYNNKTLFAALNFSSDATDFKIPNDDSSFKLEFGNYPKKEVDASSRTLKPWEGRIYISE
  
Inhibitor
Name:
BDBM175322
Synonyms:
(E)-N'-(3-bromo-4-hydroxybenzylidene)-4-(5,6-dimethyl-1H-benzo[d] imidazol-2-yl)benzohydrazide (17)
Type:
Small organic molecule
Emp. Form.:
C23H19BrN4O2
Mol. Mass.:
463.327
SMILES:
Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)N\N=C\c1ccc(O)c(Br)c1
Structure:
Search PDB for entries with ligand similarity: