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Target
G-protein coupled estrogen receptor 1
Ligand
BDBM288606
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
1.85±n/a nM
Citation
 Yu, S; Yang, F; Chen, L; Yan, J; Zhang, X; Xie, Z; Chen, L; He, M Piperidine derivative and preparation method and pharmaceutical use thereof US Patent  US10087191 Publication Date 10/2/2018 
Target
Name:
G-protein coupled estrogen receptor 1
Synonyms:
CEPR | CMKRL2 | DRY12 | G-protein coupled estrogen receptor 1 | G-protein-coupled receptor (GPR30 ) | GPER | GPER1 | GPER1_HUMAN | GPR30
Type:
PROTEIN
Mol. Mass.:
42259.21
Organism:
Homo sapiens (Human)
Description:
ChEMBL_982507
Residue:
375
Sequence:
MDVTSQARGVGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLFLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLHERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGLIWMASVSATLVPFTAVHLQHTDEACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRVLVRAHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHAALKAVIPDSTEQSDVRFSSAV
  
Inhibitor
Name:
BDBM288606
Synonyms:
US10087191, Example 8
Type:
Small organic molecule
Emp. Form.:
C29H28F3N3O2
Mol. Mass.:
507.5467
SMILES:
C[C@@H]1Cc2cc(ccc2[C@H](N1CC(C)(C)F)c1c(F)cc(\C=C\C(O)=O)cc1F)C#Cc1cnn(C)c1 |r|
Structure:
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