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Target
Beta-glucuronidase
Ligand
BDBM193669
Substrate
n/a
Meas. Tech.
β-Glucuronidase assay
IC50
1.620e+4± 4.0e+2 nM
Citation
 Taha, M; Ismail, NH; Imran, S; Wadood, A; Rahim, F; Al Muqarrabin, LM; Zaki, HM; Ahmat, N; Nasir, A; Khan, F Synthesis of novel disulfide and sulfone hybrid scaffolds as potent ß-glucuronidase inhibitor. Bioorg Chem 68:15-22 (2016) [PubMed]  Article 
Target
Name:
Beta-glucuronidase
Synonyms:
Beta-glucuronidase | Beta-glucuronidase (β-glucuronidase) | EMBL:AAI33416.1 | Ensembl:ENSBTAP00000000941 | Ensembl:ENSBTAP00000000941} | GUSB
Type:
Protein
Mol. Mass.:
74467.69
Organism:
Bos taurus (Bovine)
Description:
EC 3.2.1.31, bovine liver
Residue:
652
Sequence:
MLRGSAGAWAVLGPLLWGCGLSLLQGGMLYPRESRSRERKELDGLWSFRADFSDNRRQGFEQQWYRAPLRESGPTLDMPVPSSFNDVGQDGQLRSFVGWVWYEREITLPQRWTEDLGTRVVLRIGSAHYYAIVWVNGVHVLEHEGGHLPFEADISKLVQSGPLSSCRITIAINNTLSPHTLPPGTILYKTDPSMYPKGYFVQNTKFDFFNYAGLHRSVLLYTTPTTYIDDITVTTDMDQDIGLVNYQIIVQGSDHFQVDVSLLDEEGKVMAKGAGAEGQLQVPSAHLWWPYLMHEHPAYLYSLEVKLTAQTAVGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFRGVNKHEDADIRGKGFDWPLLVKDFNLLRWLGANAFRTSHYPYSEEVLQLCDRYGIVVIDESPGVGIVLVESFSNVSLQHHLEVMEEMIRRDKNHPAVVMWSLANEPASFLKPAGYYFKTLIAHTKALDPSRPVTFVTNTNYEADLGAPYVDIICVNSYYSWYHDYGHMEVIQLQLATQFENWYKAYQKPMIQSEYGADAIEGFHEDPPLMFSEEYQKGLLQQYHVVLDQKRKEYVVGELIWNFADFMTNQSPVRMIGNRKGIFTRQRQPKSAAFLLRERYWKLANETRYQRSAVTSQCVGSGLFTV
  
Inhibitor
Name:
BDBM193669
Synonyms:
N,N'-(disulfanediylbis(2,1-phenylene))bis(2,5-dichlorobenzenesulfonamide) (18)
Type:
Small organic molecule
Emp. Form.:
C24H16Cl4N2O4S4
Mol. Mass.:
666.467
SMILES:
Clc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccccc1SSc1ccccc1NS(=O)(=O)c1cc(Cl)ccc1Cl
Structure:
Search PDB for entries with ligand similarity: