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Target
Acetylcholinesterase
Ligand
BDBM193677
Substrate
n/a
Meas. Tech.
Acetylcholinesterase Assay
pH
7.7±n/a
IC50
1.812e+4± 2e+1 nM
Comments
extracted
Citation
 Rahim, F; Ullah, H; Taha, M; Wadood, A; Javed, MT; Rehman, W; Nawaz, M; Ashraf, M; Ali, M; Sajid, M; Ali, F; Khan, MN; Khan, KM Synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory potential of hydrazide based Schiff bases. Bioorg Chem 68:30-40 (2016) [PubMed]  Article 
Target
Name:
Acetylcholinesterase
Synonyms:
3.1.1.7 | ACES_TETCF | Acetylcholinesterase (AChE) | Acetylcholinesterase precursor | ache
Type:
n/a
Mol. Mass.:
65900.74
Organism:
Tetronarce californica (Pacific electric ray) (Torpedo californica)
Description:
P04058
Residue:
586
Sequence:
MNLLVTSSLGVLLHLVVLCQADDHSELLVNTKSGKVMGTRVPVLSSHISAFLGIPFAEPPVGNMRFRRPEPKKPWSGVWNASTYPNNCQQYVDEQFPGFSGSEMWNPNREMSEDCLYLNIWVPSPRPKSTTVMVWIYGGGFYSGSSTLDVYNGKYLAYTEEVVLVSLSYRVGAFGFLALHGSQEAPGNVGLLDQRMALQWVHDNIQFFGGDPKTVTIFGESAGGASVGMHILSPGSRDLFRRAILQSGSPNCPWASVSVAEGRRRAVELGRNLNCNLNSDEELIHCLREKKPQELIDVEWNVLPFDSIFRFSFVPVIDGEFFPTSLESMLNSGNFKKTQILLGVNKDEGSFFLLYGAPGFSKDSESKISREDFMSGVKLSVPHANDLGLDAVTLQYTDWMDDNNGIKNRDGLDDIVGDHNVICPLMHFVNKYTKFGNGTYLYFFNHRASNLVWPEWMGVIHGYEIEFVFGLPLVKELNYTAEEEALSRRIMHYWATFAKTGNPNEPHSQESKWPLFTTKEQKFIDLNTEPMKVHQRLRVQMCVFWNQFLPKLLNATACDGELSSSGTSSSKGIIFYVLFSILYLIF
  
Inhibitor
Name:
BDBM193677
Synonyms:
N'-[(Z)-(2,4-dichlorophenyl)methylidene]-2-hydroxybenzohydrazide (6)
Type:
Small organic molecule
Emp. Form.:
C14H10Cl2N2O2
Mol. Mass.:
309.147
SMILES:
Oc1ccccc1C(=O)N\N=C/c1ccc(Cl)cc1Cl
Structure:
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