Reaction Details Report a problem with these data
Target
Histone deacetylase 6 [440-798]
Ligand
BDBM198121
Substrate
n/a
Meas. Tech.
HDAC6 fluorescence anisotropy assay
Temperature
298.15±n/a K
Ki
1.0±0.2 nM
IC50
1.8±0.3 nM
Comments
extracted
Citation
 Hai, Y; University of Pennsylvania,, DW Histone deacetylase 6 structure and molecular basis of catalysis and inhibition Nat Chem Biol 12:741-747 (2016) [PubMed]  Article 
Target
Name:
Histone deacetylase 6 [440-798]
Synonyms:
Catalytic domain 2 (zCD2) | zCD2
Type:
n/a
Mol. Mass.:
39850.25
Organism:
Danio rerio
Description:
F8W4B7[440-798]
Residue:
359
Sequence:
SSPITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGDSPPSLDHLTPLKTSATVSINNVLRAHAPFWSSLR
  
Inhibitor
Name:
BDBM198121
Synonyms:
HPOB
Type:
Small organic molecule
Emp. Form.:
C17H18N2O4
Mol. Mass.:
314.3358
SMILES:
OCCN(C(=O)Cc1ccc(cc1)C(=O)NO)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: