Reaction Details
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Histone deacetylase 6 [440-798]
Ligand
BDBM198122
Substrate
n/a
Meas. Tech.
HDAC6 fluorescence anisotropy assay
Temperature
298.15±n/a K
Ki
350±50 nM
IC50
600±90 nM
Comments
extracted
Citation
Hai, Y; University of Pennsylvania,, DW Histone deacetylase 6 structure and molecular basis of catalysis and inhibition Nat Chem Biol 12:741-747 (2016) [PubMed] Article More Info.:
Target
Name:
Histone deacetylase 6 [440-798]
Synonyms:
Catalytic domain 2 (zCD2) | zCD2
Type:
n/a
Mol. Mass.:
39850.25
Organism:
Danio rerio
Description:
F8W4B7[440-798]
Residue:
359
Sequence:
SSPITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGDSPPSLDHLTPLKTSATVSINNVLRAHAPFWSSLR
Inhibitor
Name:
BDBM198122
Synonyms:
HC toxin
Type:
Small organic molecule
Emp. Form.:
C21H32N4O6
Mol. Mass.:
436.502
SMILES:
C[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCCCC(=O)[C@@H]2CO2)NC(=O)[C@@H](C)NC1=O
Structure:
