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Target
Cellular tumor antigen p53 [18-26]/Protein Mdm4 [2-185]
Ligand
BDBM236414
Substrate
n/a
Meas. Tech.
Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay
Temperature
298.15±n/a K
IC50
716.5±n/a nM
Comments
extracted
Citation
 Cotesta, S; Furet, P; Guagnano, V; Holzer, P; Kallen, J; Mah, R; Masuya, K; Schlapbach, A; Stutz, S; Vaupel, A Pyrrolopyrrolidinone compounds US Patent  US9365576 Publication Date 6/14/2016 
Target
Name:
Cellular tumor antigen p53 [18-26]/Protein Mdm4 [2-185]
Synonyms:
p53-MDM4
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Cellular tumor antigen p53 [18-26]
Synonyms:
P53 | P53_HUMAN | TP53 | Tumor suppressor p53
Type:
Protein
Mol. Mass.:
1122.31
Organism:
Homo sapiens (Human)
Description:
aa 18-26
Residue:
9
Sequence:
TFSDLWKLL
  
Component 2
Name:
Protein Mdm4 [2-185]
Synonyms:
E3 ubiquitin-protein ligase Mdm4 | MDM4 | MDM4_HUMAN | MDMX | p53-binding protein Mdm4
Type:
Protein
Mol. Mass.:
20438.64
Organism:
Homo sapiens (Human)
Description:
aa 2-185
Residue:
184
Sequence:
TSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSR
  
Inhibitor
Name:
BDBM236414
Synonyms:
US9365576, 167
Type:
Small organic molecule
Emp. Form.:
C28H26ClN7O3
Mol. Mass.:
544.004
SMILES:
COc1nc(ncc1-c1cc2C(=O)N([C@H](c2n1C(C)C)c1ccc(cc1)C#N)c1cc(Cl)c[nH]c1=O)N(C)C |r|
Structure:
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