Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Genome polyprotein [2420-3010]
Ligand
BDBM243479
Substrate
n/a
Meas. Tech.
Surface Plasmon Resonance (SPR)-Based Assay
pH
7.4±n/a
Temperature
298.15±n/a K
KOFF
3.80E-03 s-1
KON
9.50E+03 M-1s-1
Comments
extracted
Citation
Vendeville, SM; Raboisson, PJ; Lin, T; Tahri, A; Amssoms, KI Macrocyclic indole derivatives useful as hepatitis C virus inhibitors US Patent US9427440 Publication Date 8/30/2016 More Info.:
Target
Name:
Genome polyprotein [2420-3010]
Synonyms:
POLG_HCVCO | RNA polymerase (NS5B) | RNA-directed RNA polymerase (NS5B)
Type:
Enzyme
Mol. Mass.:
65783.36
Organism:
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
Description:
aa 2420-3010
Residue:
591
Sequence:
SMSYTWTGALITPCAAEETKLPINALSNSLLRHHNLVYATTSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSARSKFGYGAKDVRNLSSKAVNHIRSVWKDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPGQRVEFLVNAWKAKKCPMGFAYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAAAACRAAKLQDCTMLVCGDDLVVICESAGTQEDEASLRAFTEAMTRYSAPPGDPPKPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIQRLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVRTKLKLTPIPAASQLDLSSWFVAGYSGGDIYHSLSRARPRWFMWCLLLLSVGVGIYLLPNR
Inhibitor
Name:
BDBM243479
Synonyms:
US9427440, 27
Type:
Small organic molecule
Emp. Form.:
C31H35ClN4O4S
Mol. Mass.:
595.152
SMILES:
CN1CCCCCNC(=O)C2=Cc3ccc(Cl)cc3-c3c(C4CCCCC4)c4ccc(cc4n3C2)C(=O)NS1(=O)=O |t:10|
Structure:
