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Target
Protein mono-ADP-ribosyltransferase PARP14 [1611-1801]
Ligand
BDBM434135
Substrate
n/a
Meas. Tech.
Enzymatic Inhibition Assay
IC50
<1000±n/a nM
Citation
 Schenkel, LB; Vasbinder, MM; Kuntz, KW; Swinger, KK Quinazolinones as PARP14 inhibitors US Patent  US10562891 Publication Date 2/18/2020 
Target
Name:
Protein mono-ADP-ribosyltransferase PARP14 [1611-1801]
Synonyms:
BAL2 | KIAA1268 | PAR14_HUMAN | PARP14 | Protein mono-ADP-ribosyltransferase PARP14 (aa 1611-1801)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21749.94
Organism:
Homo sapiens (Human)
Description:
aa 1611-1801
Residue:
190
Sequence:
DMKQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQAKKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSYAGKNAVAYGKGTYFAVNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQNPTDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFR
  
Inhibitor
Name:
BDBM434135
Synonyms:
US10562891, Example 57 | US11008308, Example 58
Type:
Small organic molecule
Emp. Form.:
C16H19FN2O2S
Mol. Mass.:
322.398
SMILES:
Cc1ccc(F)c2c1nc(CS[C@@H]1CC[C@H](O)CC1)[nH]c2=O |r,wU:12.12,15.16,(-5.33,-7.93,;-5.33,-6.39,;-6.67,-5.62,;-6.67,-4.08,;-5.33,-3.31,;-5.33,-1.77,;-4,-4.08,;-4,-5.62,;-2.67,-6.39,;-1.33,-5.62,;,-6.39,;1.33,-5.62,;2.67,-6.39,;2.67,-7.93,;4,-8.7,;5.33,-7.93,;6.67,-8.7,;5.33,-6.39,;4,-5.62,;-1.33,-4.08,;-2.67,-3.31,;-2.67,-1.77,)|
Structure:
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