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Target
Protein mono-ADP-ribosyltransferase PARP14 [1611-1801]
Ligand
BDBM434136
Substrate
n/a
Meas. Tech.
Enzymatic Inhibition Assay
IC50
<1000±n/a nM
Citation
 Schenkel, LB; Vasbinder, MM; Kuntz, KW; Swinger, KK Quinazolinones as PARP14 inhibitors US Patent  US10562891 Publication Date 2/18/2020 
Target
Name:
Protein mono-ADP-ribosyltransferase PARP14 [1611-1801]
Synonyms:
BAL2 | KIAA1268 | PAR14_HUMAN | PARP14 | Protein mono-ADP-ribosyltransferase PARP14 (aa 1611-1801)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21749.94
Organism:
Homo sapiens (Human)
Description:
aa 1611-1801
Residue:
190
Sequence:
DMKQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQAKKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSYAGKNAVAYGKGTYFAVNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQNPTDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFR
  
Inhibitor
Name:
BDBM434136
Synonyms:
US10562891, Example 58
Type:
Small organic molecule
Emp. Form.:
C16H19FN2O2S
Mol. Mass.:
322.398
SMILES:
Cc1ccc(F)c2c1nc(CS[C@@H]1CC[C@H](O)CC1)[nH]c2=O |r,wD:12.12,15.16,(2.67,-4.62,;2.67,-3.08,;1.33,-2.31,;1.33,-.77,;2.67,,;2.67,1.54,;4,-.77,;4,-2.31,;5.33,-3.08,;6.67,-2.31,;8,-3.08,;9.34,-2.31,;10.67,-3.08,;12,-2.31,;13.34,-3.08,;13.34,-4.62,;14.67,-5.39,;12,-5.39,;10.67,-4.62,;6.67,-.77,;5.33,,;5.33,1.54,)|
Structure:
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