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Target
Protein mono-ADP-ribosyltransferase PARP14 [1611-1801]
Ligand
BDBM434179
Substrate
n/a
Meas. Tech.
Enzymatic Inhibition Assay
IC50
<1000±n/a nM
Citation
 Schenkel, LB; Vasbinder, MM; Kuntz, KW; Swinger, KK Quinazolinones as PARP14 inhibitors US Patent  US10562891 Publication Date 2/18/2020 
Target
Name:
Protein mono-ADP-ribosyltransferase PARP14 [1611-1801]
Synonyms:
BAL2 | KIAA1268 | PAR14_HUMAN | PARP14 | Protein mono-ADP-ribosyltransferase PARP14 (aa 1611-1801)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21749.94
Organism:
Homo sapiens (Human)
Description:
aa 1611-1801
Residue:
190
Sequence:
DMKQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQAKKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSYAGKNAVAYGKGTYFAVNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQNPTDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFR
  
Inhibitor
Name:
BDBM434179
Synonyms:
US10562891, Example 101 | US11008308, Example 101
Type:
Small organic molecule
Emp. Form.:
C20H22N4O2S
Mol. Mass.:
382.479
SMILES:
O[C@H]1CC[C@@H](CC1)SCc1nc2cc(Nc3cccnc3)ccc2c(=O)[nH]1 |r,wU:4.7,wD:1.0,(-6.67,2.31,;-5.33,1.54,;-5.33,,;-4,-.77,;-2.67,,;-2.67,1.54,;-4,2.31,;-1.33,-.77,;;1.33,-.77,;2.67,,;4,-.77,;5.33,,;6.67,-.77,;8,,;9.34,-.77,;9.34,-2.31,;10.67,-3.08,;12,-2.31,;12,-.77,;10.67,,;6.67,-2.31,;5.33,-3.08,;4,-2.31,;2.67,-3.08,;2.67,-4.62,;1.33,-2.31,)|
Structure:
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