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Target
Protein mono-ADP-ribosyltransferase PARP14 [1611-1801]
Ligand
BDBM434181
Substrate
n/a
Meas. Tech.
Enzymatic Inhibition Assay
IC50
<1000±n/a nM
Citation
 Schenkel, LB; Vasbinder, MM; Kuntz, KW; Swinger, KK Quinazolinones as PARP14 inhibitors US Patent  US10562891 Publication Date 2/18/2020 
Target
Name:
Protein mono-ADP-ribosyltransferase PARP14 [1611-1801]
Synonyms:
BAL2 | KIAA1268 | PAR14_HUMAN | PARP14 | Protein mono-ADP-ribosyltransferase PARP14 (aa 1611-1801)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21749.94
Organism:
Homo sapiens (Human)
Description:
aa 1611-1801
Residue:
190
Sequence:
DMKQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQAKKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSYAGKNAVAYGKGTYFAVNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQNPTDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFR
  
Inhibitor
Name:
BDBM434181
Synonyms:
US10562891, Example 103 | US11008308, Example 103
Type:
Small organic molecule
Emp. Form.:
C20H27N3O2S
Mol. Mass.:
373.512
SMILES:
O[C@H]1CC[C@H](CC1)SCc1nc2cc(NC3CCCC3)ccc2c(=O)[nH]1 |r,wD:4.7,1.0,(14.67,-5.39,;13.34,-4.62,;13.34,-3.08,;12,-2.31,;10.67,-3.08,;10.67,-4.62,;12,-5.39,;9.34,-2.31,;8,-3.08,;6.67,-2.31,;5.33,-3.08,;4,-2.31,;2.67,-3.08,;1.33,-2.31,;,-3.08,;-1.33,-2.31,;-2.74,-2.94,;-3.77,-1.79,;-3,-.46,;-1.49,-.78,;1.33,-.77,;2.67,,;4,-.77,;5.33,,;5.33,1.54,;6.67,-.77,)|
Structure:
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