Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Protein mono-ADP-ribosyltransferase PARP14 [1611-1801]
Ligand
BDBM434214
Substrate
n/a
Meas. Tech.
Enzymatic Inhibition Assay
IC50
<1000±n/a nM
Citation
Schenkel, LB; Vasbinder, MM; Kuntz, KW; Swinger, KK Quinazolinones as PARP14 inhibitors US Patent US10562891 Publication Date 2/18/2020 More Info.:
Target
Name:
Protein mono-ADP-ribosyltransferase PARP14 [1611-1801]
Synonyms:
BAL2 | KIAA1268 | PAR14_HUMAN | PARP14 | Protein mono-ADP-ribosyltransferase PARP14 (aa 1611-1801)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21749.94
Organism:
Homo sapiens (Human)
Description:
aa 1611-1801
Residue:
190
Sequence:
DMKQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQAKKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSYAGKNAVAYGKGTYFAVNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQNPTDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFR
Inhibitor
Name:
BDBM434214
Synonyms:
US10562891, Example 136 | US11008308, Example 136
Type:
Small organic molecule
Emp. Form.:
C22H31N3O2S
Mol. Mass.:
401.565
SMILES:
OC[C@H]1CC[C@@H](CC1)SCc1nc2cc(NC3CCCCC3)ccc2c(=O)[nH]1 |r,wU:5.8,wD:2.1,(10,3.09,;8.67,2.32,;7.34,3.09,;7.34,4.63,;6,5.4,;4.67,4.63,;4.67,3.09,;6,2.32,;3.33,5.4,;2,4.63,;.67,5.4,;-.67,4.63,;-2,5.4,;-3.33,4.63,;-4.67,5.4,;-6,4.63,;-7.34,5.4,;-7.34,6.94,;-8.67,7.71,;-10,6.94,;-10,5.4,;-8.67,4.63,;-4.67,6.94,;-3.33,7.71,;-2,6.94,;-.67,7.71,;-.67,9.25,;.67,6.94,)|
Structure:
