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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM445132
Substrate
n/a
Meas. Tech.
UCHL1 Biochemical IC50 Assay
IC50
550±n/a nM
Citation
 Kemp, M; Stockley, M; Jones, A Cyanopyrrolidines as dub inhibitors for the treatment of cancer US Patent  US10669234 Publication Date 6/2/2020 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
Neuron cytoplasmic protein 9.5 | PGP 9.5 | PGP9.5 | UCH-L1 | UCHL1 | UCHL1_HUMAN | Ubiquitin thioesterase L1
Type:
PROTEIN
Mol. Mass.:
24819.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_974327
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM445132
Synonyms:
(2S,4S)-1-Cyano-4-methoxy-N-methyl-N-(4-phenylthiazol-2-yl)pyrrolidine-2-carboxamide | US10669234, Example 71 | US11319287, Example 71
Type:
Small organic molecule
Emp. Form.:
C21H27N3O4S
Mol. Mass.:
417.522
SMILES:
CO[C@H]1C[C@H](N(C1)C(=O)OC(C)(C)C)C(=O)N(C)c1nc(cs1)-c1ccccc1 |r|
Structure:
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