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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM445137
Substrate
n/a
Meas. Tech.
UCHL1 Biochemical IC50 Assay
IC50
550±n/a nM
Citation
 Kemp, M; Stockley, M; Jones, A Cyanopyrrolidines as dub inhibitors for the treatment of cancer US Patent  US10669234 Publication Date 6/2/2020 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
Neuron cytoplasmic protein 9.5 | PGP 9.5 | PGP9.5 | UCH-L1 | UCHL1 | UCHL1_HUMAN | Ubiquitin thioesterase L1
Type:
PROTEIN
Mol. Mass.:
24819.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_974327
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM445137
Synonyms:
(S)-2-(4-(2-Aminopyridin-4-yl)indoline-1-carbonyl)pyrrolidine-1-carbonitrile | US10669234, Example 76 | US11319287, Example 76
Type:
Small organic molecule
Emp. Form.:
C23H28N4O3
Mol. Mass.:
408.4934
SMILES:
CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCc2c1cccc2-c1ccnc(N)c1 |r|
Structure:
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