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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM445158
Substrate
n/a
Meas. Tech.
UCHL1 Biochemical IC50 Assay
IC50
<100±n/a nM
Citation
 Kemp, M; Stockley, M; Jones, A Cyanopyrrolidines as dub inhibitors for the treatment of cancer US Patent  US10669234 Publication Date 6/2/2020 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
Neuron cytoplasmic protein 9.5 | PGP 9.5 | PGP9.5 | UCH-L1 | UCHL1 | UCHL1_HUMAN | Ubiquitin thioesterase L1
Type:
PROTEIN
Mol. Mass.:
24819.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_974327
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM445158
Synonyms:
(S)-2-(5-(3-(trifluoro- methyl)-1H-pyrazol-4- yl)isoindoline-2- carbonyl)pyrrolidine-1- carbonitrile | US10669234, Example 115 | US11319287, Example 115
Type:
Small organic molecule
Emp. Form.:
C18H16F3N5O
Mol. Mass.:
375.3477
SMILES:
FC(F)(F)c1n[nH]cc1-c1ccc2CN(Cc2c1)C(=O)[C@@H]1CCCN1C#N
Structure:
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