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Target
Activin receptor type-1 [172-499]
Ligand
BDBM451791
Substrate
n/a
Meas. Tech.
ADPGlo Assay
IC50
9.00±n/a nM
Citation
 Arista, L; Babu, S; Bian, J; Cui, K; Dillon, MP; Lattmann, R; Li, J; Liao, L; Lizos, D; Ramos, R; Stiefl, NJ; Ullrich, T; Usselmann, P; Wang, X; Waykole, LM; Weiler, S; Zhang, Y; Zhou, Y; Zhu, T Aminopyridine derivatives and their use as selective ALK-2 inhibitors US Patent  US10710980 Publication Date 7/14/2020 
Target
Name:
Activin receptor type-1 [172-499]
Synonyms:
ACVR1 | ACVR1_HUMAN | ACVRLK2 | Activin receptor type-1 (ACVR1) | Activin receptor-like kinase 2 (ALK-2)(aa 172-499) | Activin receptor-like kinase 2 (ALK2)(172-499)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37139.64
Organism:
Homo sapiens (Human)
Description:
aa 172-499
Residue:
328
Sequence:
TTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKID
  
Inhibitor
Name:
BDBM451791
Synonyms:
US10710980, Example 23 | US10947218, Example 23
Type:
Small organic molecule
Emp. Form.:
C25H32N4O2
Mol. Mass.:
420.5472
SMILES:
Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(CN2CC3(CCC3)C2)cc1 |r,wU:10.10,wD:13.14,(-4.25,3.17,;-2.92,2.4,;-1.59,3.17,;-.25,2.4,;-.25,.86,;-1.59,.09,;-2.92,.86,;-4.25,.09,;-4.25,-1.45,;-5.59,.86,;-6.92,.09,;-6.52,-1.39,;-7.61,-2.48,;-9.1,-2.08,;-10.19,-3.17,;-9.5,-.6,;-8.41,.49,;1.08,.09,;1.08,-1.45,;2.41,-2.22,;3.75,-1.45,;5.08,-2.22,;6.42,-1.45,;7.9,-1.85,;8.3,-.36,;9.79,-.76,;10.19,.73,;8.7,1.13,;6.81,.04,;3.75,.09,;2.41,.86,)|
Structure:
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