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Target
Vasopressin V2 receptor
Ligand
BDBM192454
Substrate
n/a
Meas. Tech.
Cellular In Vitro Assay for Determining Vasopressin V2 Receptor Activity
IC50
32.6±n/a nM
Citation
 Schmeck, C; Engelen, A; Kolkhof, P; Lustig, K; Pook, E; Wasnaire, P Oxoalkyl-substituted phenyltriazole derivatives and uses thereof US Patent  US10800746 Publication Date 10/13/2020 
Target
Name:
Vasopressin V2 receptor
Synonyms:
ADHR | AVPR V2 | AVPR2 | Antidiuretic hormone receptor | DIR | DIR3 | Renal-type arginine vasopressin receptor | V2R | V2R_HUMAN | VASOPRESSIN V2 | Vasopressin V2 receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
40295.28
Organism:
Homo sapiens (Human)
Description:
P30518
Residue:
371
Sequence:
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
  
Inhibitor
Name:
BDBM192454
Synonyms:
US10800746, Example WO 2011/104322 60 | US9187466, 60 | US9687476, 60
Type:
Small organic molecule
Emp. Form.:
C22H17Cl2F3N6O4
Mol. Mass.:
557.309
SMILES:
O[C@@H](Cn1c(nn(Cc2nc(-c3ccccc3Cl)n(CC(O)=O)n2)c1=O)-c1ccc(Cl)cc1)C(F)(F)F |r|
Structure:
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