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Target
Histone deacetylase 3
Ligand
BDBM468602
Substrate
n/a
Meas. Tech.
HDAC Inhibition
IC50
150±n/a nM
Citation
 Liao, D; Roush, WR; Stowe, RL HDAC inhibitor compounds and methods of treatment US Patent  US10807944 Publication Date 10/20/2020 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Human
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM468602
Synonyms:
US10807944, Compound RLS2-312 | US11731934, Compound RLS2-312
Type:
Small organic molecule
Emp. Form.:
C12H17N5O
Mol. Mass.:
247.2963
SMILES:
CCCCNNC(=O)c1ccc(CN=[N+]=[N-])cc1
Structure:
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