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Target
Histone deacetylase 8
Ligand
BDBM468609
Substrate
n/a
Meas. Tech.
HDAC Inhibition
IC50
2430±n/a nM
Citation
 Liao, D; Roush, WR; Stowe, RL HDAC inhibitor compounds and methods of treatment US Patent  US10807944 Publication Date 10/20/2020 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM468609
Synonyms:
US10807944, Compound RLS3-43 | US10870618, Compound 1e | US11731934, Compound SR-3558
Type:
Small organic molecule
Emp. Form.:
C17H20N2O
Mol. Mass.:
268.3535
SMILES:
CCCCNNC(=O)c1ccc(cc1)-c1ccccc1
Structure:
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