Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM468578
Substrate
n/a
Meas. Tech.
TBD
IC50
<1000±n/a nM
Citation
 Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X; Greenlee, W Compounds for treatment of immune inflammatory disorders US Patent  US10807952 Publication Date 10/20/2020 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM468578
Synonyms:
(2S,3R)-2-(2-(3- acetyl-1H-indol-1- yl)acetamido)-N- (2'-chloro-2- fluorobiphenyl-3- yl)-3- hydroxybutanamide | US10807952, Cmp No. 7
Type:
Small organic molecule
Emp. Form.:
C28H25ClFN3O4
Mol. Mass.:
521.967
SMILES:
C[C@@H](O)[C@H](NC(=O)Cn1cc(C(C)=O)c2ccccc12)C(=O)Nc1cccc(c1F)-c1ccccc1Cl |r|
Structure:
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