Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM468579
Substrate
n/a
Meas. Tech.
TBD
IC50
<1000±n/a nM
Citation
Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X; Greenlee, W Compounds for treatment of immune inflammatory disorders US Patent US10807952 Publication Date 10/20/2020
More Info.:
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
Inhibitor
Name:
BDBM468579
Synonyms:
1-(2-((2S,4R)-2-(2'- chloro-2-fluoro-5'- ((E)-1- (methoxyimino) ethyl)biphenyl-3- ylcarbamoyl)-4- fluoropyrrolidin-1- yl)-2-oxoethyl)-1H- indazole-3- carboxamide | US10807952, Cmp No. 8
Type:
Small organic molecule
Emp. Form.:
C30H27ClF2N6O4
Mol. Mass.:
609.023
SMILES:
CO\N=C(/C)c1ccc(Cl)c(c1)-c1cccc(NC(=O)[C@@H]2C[C@@H](F)CN2C(=O)Cn2nc(C(N)=O)c3ccccc23)c1F |r|