Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM468672
Substrate
n/a
Meas. Tech.
TBD
IC50
<1000±n/a nM
Citation
 Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X; Greenlee, W Compounds for treatment of immune inflammatory disorders US Patent  US10807952 Publication Date 10/20/2020 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM468672
Synonyms:
(4R)-1-(2-(3- carbamoyl-5- hydroxyphenyl)acetyl)- N-(2'-chloro-2- fluoro-[1,1'- biphenyl]-3-yl)-4- fluoropyrrolidine-2- carboxamide | US10807952, Cmp No. 78
Type:
Small organic molecule
Emp. Form.:
C26H22ClF2N3O4
Mol. Mass.:
513.92
SMILES:
NC(=O)c1cc(O)cc(CC(=O)N2C[C@H](F)CC2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c1 |r|
Structure:
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