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Target
WD repeat-containing protein 5
Ligand
BDBM468814
Substrate
n/a
Meas. Tech.
TR-FRET Binding Assay
Ki
0.150±n/a nM
Citation
 Gogliotti, RD; Stauffer, SR; Jeon, K; Salovich, JM; Macdonald, JD; Mills, JJ; Meyers, KM; Alvarado, JR; Han, C; Fesik, SW; Lee, T WDR5-MLL1 inhibitors and modulators US Patent  US10807959 Publication Date 10/20/2020 
Target
Name:
WD repeat-containing protein 5
Synonyms:
BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN
Type:
Protein
Mol. Mass.:
36597.13
Organism:
Homo sapiens (Human)
Description:
P61964
Residue:
334
Sequence:
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
  
Inhibitor
Name:
BDBM468814
Synonyms:
US10807959, Example 84
Type:
Small organic molecule
Emp. Form.:
C23H22Cl2N6O
Mol. Mass.:
469.366
SMILES:
Cc1cnccc1-c1cc(CNC2=NCCN2)cc(n1)C(=O)NCc1ccc(Cl)c(Cl)c1 |t:13|
Structure:
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