Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM351988
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<1000±n/a nM
Citation
 Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders US Patent  US10822352 Publication Date 11/3/2020 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM351988
Synonyms:
1-(2-((1R,3S,5R)-3-(2'- chloro-2- fluorobiphenyl-3- ylcarbamoyl)-2- azabicyclo[3.1.0]hexan- 2-yl)-2-oxoethyl)-5- (pyrimidin-2-yl)-1H- indazole-3-carboxamide | US10287301, Compound 7 | US10822352, Comp No. 7 | US9796741, cmp No. 7
Type:
Small organic molecule
Emp. Form.:
C32H25ClFN7O3
Mol. Mass.:
610.037
SMILES:
NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c2ccc(cc12)-c1ncccn1 |r|
Structure:
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