Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM351990
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<1000±n/a nM
Citation
 Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders US Patent  US10822352 Publication Date 11/3/2020 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM351990
Synonyms:
1-(2-((2S,4R)-4-fluoro- 2-(2-fluoro-3- (trifluoromethoxy) phenylcarbamoyl) pyrrolidin-1-yl)-2- oxoethyl)-5-(pyrimidin- 5-yl)-1H-indazole-3- carboxamide | US10287301, Compound 9 | US10822352, Comp No. 9 | US9796741, cmp No. 9
Type:
Small organic molecule
Emp. Form.:
C26H20F5N7O4
Mol. Mass.:
589.4735
SMILES:
NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(OC(F)(F)F)c2F)c2ccc(cc12)-c1cncnc1 |r|
Structure:
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