Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM352488
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<1000±n/a nM
Citation
 Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders US Patent  US10822352 Publication Date 11/3/2020 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM352488
Synonyms:
(2S,4R)-1-(2-(3-acetyl- 5-(4-(5- fluoropyrimidin-2- yl)piperazin-1-yl)-1H- indol-1-yl)acetyl)-N- (2'-chloro-2- fluorobiphenyl-3-yl)-4- fluoropyrrolidine-2- carboxamide | US10287301, Compound 32 | US10822352, Comp No. 32 | US9796741, cmp No. 32
Type:
Small organic molecule
Emp. Form.:
C37H33ClF3N7O3
Mol. Mass.:
716.151
SMILES:
CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c2ccc(cc12)N1CCN(CC1)c1ncc(F)cn1 |r|
Structure:
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