Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM354162
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<1000±n/a nM
Citation
Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders US Patent US10822352 Publication Date 11/3/2020
More Info.:
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
Inhibitor
Name:
BDBM354162
Synonyms:
(2S,4R)-1-(2-(3-acetyl- 5-(pyridazin-4-yl)-1H- indol-1-yl)acetyl)-N-(5- chloropyridin-3-yl)-4- fluoropyrrolidine-2- carboxamide | US10287301, Compound 66 | US10822352, Comp No. 66 | US9796741, cmp No. 66
Type:
Small organic molecule
Emp. Form.:
C26H22ClFN6O3
Mol. Mass.:
520.943
SMILES:
CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cncc(Cl)c2)c2ccc(cc12)-c1ccnnc1 |r|