Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM354172
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<1000±n/a nM
Citation
 Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders US Patent  US10822352 Publication Date 11/3/2020 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM354172
Synonyms:
1-(2-((2S,4R)-2-(2,2- dimethyl-2,3- dihydrobenzofuran-6- ylcarbamoyl)-4- fluoropyrrolidin-1-yl)- 2-oxoethyl)-5- (pyridazin-4-yl)-1H- indazole-3-carboxamide | US10287301, Compound 76 | US10822352, Comp No. 76 | US9796741, cmp No. 76
Type:
Small organic molecule
Emp. Form.:
C29H28FN7O4
Mol. Mass.:
557.5755
SMILES:
CC1(C)Cc2ccc(NC(=O)[C@@H]3C[C@@H](F)CN3C(=O)Cn3nc(C(N)=O)c4cc(ccc34)-c3ccnnc3)cc2O1 |r|
Structure:
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