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Target
Ubiquitin carboxyl-terminal hydrolase 7 [208-1102]
Ligand
BDBM421831
Substrate
n/a
Meas. Tech.
USP7 Assay A (Ubitquin-Rhodamine 110 Assay)
IC50
5500±n/a nM
Citation
 Ioannidis, S; Talbot, AC; Follows, B; Buckmelter, AJ; Wang, M; Campbell, A; Lancia, Jr., DR Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors US Patent  US10836741 Publication Date 11/17/2020 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 7 [208-1102]
Synonyms:
HAUSP | UBP7_HUMAN | USP7 | USP7 (aa 208-1102)
Type:
PROTEIN
Mol. Mass.:
104393.08
Organism:
Homo sapiens (Human)
Description:
Q93009[208-1102]
Residue:
895
Sequence:
KKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQLVERLQEEKRIEAQKRKERQEAHLYMQVQIVAEDQFCGHQGNDMYDEEKVKYTVFKVLKNSSLAEFVQSLSQTMGFPQDQIRLWPMQARSNGTKRPAMLDNEADGNKTMIELSDNENPWTIFLETVDPELAASGATLPKFDKDHDVMLFLKMYDPKTRSLNYCGHIYTPISCKIRDLLPVMCDRAGFIQDTSLILYEEVKPNLTERIQDYDVSLDKALDELMDGDIIVFQKDDPENDNSELPTAKEYFRDLYHRVDVIFCDKTIPNDPGFVVTLSNRMNYFQVAKTVAQRLNTDPMLLQFFKSQGYRDGPGNPLRHNYEGTLRDLLQFFKPRQPKKLYYQQLKMKITDFENRRSFKCIWLNSQFREEEITLYPDKHGCVRDLLEECKKAVELGEKASGKLRLLEIVSYKIIGVHQEDELLECLSPATSRTFRIEEIPLDQVDIDKENEMLVTVAHFHKEVFGTFGIPFLLRIHQGEHFREVMKRIQSLLDIQEKEFEKFKFAIVMMGRHQYINEDEYEVNLKDFEPQPGNMSHPRPWLGLDHFNKAPKRSRYTYLEKAIKIHN
  
Inhibitor
Name:
BDBM421831
Synonyms:
3-((1-(4-fluorobenzoyl)-4-hydroxypiperidin-4-yl)methyl)-8-(4-fluorophenoxy)quinazolin-4(3H)-one | US10508098, Example I-10 | US10513507, Example I-10 | US10836741, Example I-10
Type:
Small organic molecule
Emp. Form.:
C27H23F2N3O4
Mol. Mass.:
491.486
SMILES:
OC1(Cn2cnc3c(Oc4ccc(F)cc4)cccc3c2=O)CCN(CC1)C(=O)c1ccc(F)cc1
Structure:
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