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Target
Ubiquitin carboxyl-terminal hydrolase 7 [208-1102]
Ligand
BDBM421833
Substrate
n/a
Meas. Tech.
USP7 Assay A (Ubitquin-Rhodamine 110 Assay)
IC50
5500±n/a nM
Citation
 Ioannidis, S; Talbot, AC; Follows, B; Buckmelter, AJ; Wang, M; Campbell, A; Lancia, Jr., DR Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors US Patent  US10836741 Publication Date 11/17/2020 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 7 [208-1102]
Synonyms:
HAUSP | UBP7_HUMAN | USP7 | USP7 (aa 208-1102)
Type:
PROTEIN
Mol. Mass.:
104393.08
Organism:
Homo sapiens (Human)
Description:
Q93009[208-1102]
Residue:
895
Sequence:
KKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQLVERLQEEKRIEAQKRKERQEAHLYMQVQIVAEDQFCGHQGNDMYDEEKVKYTVFKVLKNSSLAEFVQSLSQTMGFPQDQIRLWPMQARSNGTKRPAMLDNEADGNKTMIELSDNENPWTIFLETVDPELAASGATLPKFDKDHDVMLFLKMYDPKTRSLNYCGHIYTPISCKIRDLLPVMCDRAGFIQDTSLILYEEVKPNLTERIQDYDVSLDKALDELMDGDIIVFQKDDPENDNSELPTAKEYFRDLYHRVDVIFCDKTIPNDPGFVVTLSNRMNYFQVAKTVAQRLNTDPMLLQFFKSQGYRDGPGNPLRHNYEGTLRDLLQFFKPRQPKKLYYQQLKMKITDFENRRSFKCIWLNSQFREEEITLYPDKHGCVRDLLEECKKAVELGEKASGKLRLLEIVSYKIIGVHQEDELLECLSPATSRTFRIEEIPLDQVDIDKENEMLVTVAHFHKEVFGTFGIPFLLRIHQGEHFREVMKRIQSLLDIQEKEFEKFKFAIVMMGRHQYINEDEYEVNLKDFEPQPGNMSHPRPWLGLDHFNKAPKRSRYTYLEKAIKIHN
  
Inhibitor
Name:
BDBM421833
Synonyms:
3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)pyrido[3,4-d]pyrimidin-4(3H)-one | US10508098, Example I-12 | US10513507, Example I-12 | US10836741, Example I-12
Type:
Small organic molecule
Emp. Form.:
C23H26N4O3
Mol. Mass.:
406.4775
SMILES:
CC(CC(=O)N1CCC(O)(Cn2cnc3cnccc3c2=O)CC1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: