Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase SYK
Ligand
BDBM473127
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
7100±n/a nM
Citation
Blomgren, PA; Currie, KS; Kropf, JE; Lee, SH; Mitchell, SA; Schmitt, AC; Xu, J; Zhao, Z Imidazopyridines Syk inhibitors US Patent US10842803 Publication Date 11/24/2020
More Info.:
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
Inhibitor
Name:
BDBM473127
Synonyms:
2-(6-(8-(6,7-dihydro-4H- pyrazolo[5,1- c][1,4]oxazin-2- ylamino)imidazo[1,2- a]pyridin-6-yl)-1H- indol-3-yl)ethanol | US10842803, Structure TABLE 1.57
Type:
Small organic molecule
Emp. Form.:
C23H22N6O2
Mol. Mass.:
414.4598
SMILES:
OCCc1c[nH]c2cc(ccc12)-c1cc(Nc2cc3COCCn3n2)c2nccn2c1