Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase SYK
Ligand
BDBM473159
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
17000±n/a nM
Citation
Blomgren, PA; Currie, KS; Kropf, JE; Lee, SH; Mitchell, SA; Schmitt, AC; Xu, J; Zhao, Z Imidazopyridines Syk inhibitors US Patent US10842803 Publication Date 11/24/2020
More Info.:
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
Inhibitor
Name:
BDBM473159
Synonyms:
6-(5-chloro-8-(5-(4- isopropylpiperazin-1- yl)pyridin-2- ylamino)imidazo[1,2- a]pyridin-6-yl)indolin-2- one | US10842803, Structure TABLE 1.89
Type:
Small organic molecule
Emp. Form.:
C27H28ClN7O
Mol. Mass.:
502.011
SMILES:
CC(C)N1CCN(CC1)c1ccc(Nc2cc(c(Cl)n3ccnc23)-c2ccc3CC(=O)Nc3c2)nc1