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Target
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Ligand
BDBM474210
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
15.0±n/a nM
Citation
 Kehler, J; Rasmussen, LK; Langgård, M; Jessing, M; Vital, PJ; Juhl, K Combinations comprising substituted imidazo[1,5-a]pyrazinones as PDE1 inhibitors US Patent  US10912773 Publication Date 2/9/2021 
Target
Name:
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Synonyms:
63 kDa Cam-PDE | Calcium/calmodulin-dependent 3 ,5 -cyclic nucleotide phosphodiesterase 1B | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Cam-PDE 1B | PDE1B | PDE1B1 | PDE1B_HUMAN | PDES1B | Phosphodiesterase 1B | Phosphodiesterase 1B (PDE1B1) | Phosphodiesterase Type 1 (PDE1B) | Phosphodiesterase, PDE1/PDE5
Type:
Enzyme
Mol. Mass.:
61366.51
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
536
Sequence:
MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNLEYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPKALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVSFRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD
  
Inhibitor
Name:
BDBM474210
Synonyms:
7-(4-methoxybenzyl)-6-methyl-3- (1-(4-methylthiazol-2- yl)ethyl)imidazo[1,5-a]pyrazin- 8(7H)-one | US10858362, Example 90 | US10912773, Example 90 | US11472810, Example 90
Type:
Small organic molecule
Emp. Form.:
C21H22N4O2S
Mol. Mass.:
394.49
SMILES:
COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C(C)c2nc(C)cs2)cc1
Structure:
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