Reaction Details Report a problem with these data
Target
Ubiquitin carboxyl-terminal hydrolase 25
Ligand
BDBM482031
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
1100±n/a nM
Citation
 Guerin, DJ; Bair, KW; Caravella, JA; Ioannidis, Jr., S; Lancia, Jr., DR; Li, H; Mischke, S; Ng, PY; Richard, D; Schiller, SE; Shelekhin, T; Wang, Z Thienopyridine carboxamides as ubiquitin-specific protease inhibitors US Patent  US10913753 Publication Date 2/9/2021 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 25
Synonyms:
3.4.19.12 | Deubiquitinating enzyme 25 | UBP25_HUMAN | USP on chromosome 21 | USP21 | USP25 | Ubiquitin carboxyl-terminal hydrolase 25 | Ubiquitin thioesterase 25 | Ubiquitin-specific-processing protease 25
Type:
PROTEIN
Mol. Mass.:
122185.70
Organism:
Homo sapiens
Description:
ChEMBL_118220
Residue:
1055
Sequence:
MTVEQNVLQQSAAQKHQQTFLNQLREITGINDTQILQQALKDSNGNLELAVAFLTAKNAKTPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRETGITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFYGRFLAVGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSENSGKSGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIKREEIKRLKDYLTVLQQRLERYLSYGSGPKRFPLVDVLQYALEFASSKPVCTSPVDDIDASSPPSGSIPSQTLPSTTEQQGALSSELPSTSPSSVAAISSRSVIHKPFTQSRIPPDLPMHPAPRHITEEELSVLESCLHRWRTEIENDTRDLQESISRIHRTIELMYSDKSMIQVPYRLHAVLVHEGQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSFGGYRNASAYCLMYINDKAQFLIQEEFNKETGQPLVGIETLPPDLRDFVEEDNQRFEKELEEWDAQLAQKALQEKLLASQKLRESETSVTTAQAAGDPEYLEQPSRSDFSKHLKEETIQIITKASHEHEDKSPETVLQSAIKLEYARLVKLAQEDTPPETDYRLHHVVVYFIQNQAPKKIIEKTLLEQFGDRNLSFDERCHNIMKVAQAKLEMIKPEEVNLEEYEEWHQDYRKFRETTMYLIIGLENFQRESYIDSLLFLICAYQNNKELLSKGLYRGHDEELISHYRRECLLKLNEQAAELFESGEDREVNNGLIIMNEFIVPFLPLLLVDEMEEKDILAVEDMRNRWCSYLGQEMEPHLQEKLTDFLPKLLDCSMEIKSFHEPPKLPSYSTHELCERFARIMLSLSRTPADGR
  
Inhibitor
Name:
BDBM482031
Synonyms:
US10913753, Compound I-98
Type:
Small organic molecule
Emp. Form.:
C24H27F2N5OS
Mol. Mass.:
471.566
SMILES:
C[C@@H](CNC(=O)c1sc2nc(C)ccc2c1N)c1cc(F)c(cc1F)N1CC2CCC(C1)N2 |r,TLB:21:25:32:28.29|
Structure:
Search PDB for entries with ligand similarity: