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Target
Ubiquitin carboxyl-terminal hydrolase 25
Ligand
BDBM482065
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
<200±n/a nM
Citation
 Guerin, DJ; Bair, KW; Caravella, JA; Ioannidis, Jr., S; Lancia, Jr., DR; Li, H; Mischke, S; Ng, PY; Richard, D; Schiller, SE; Shelekhin, T; Wang, Z Thienopyridine carboxamides as ubiquitin-specific protease inhibitors US Patent  US10913753 Publication Date 2/9/2021 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 25
Synonyms:
3.4.19.12 | Deubiquitinating enzyme 25 | UBP25_HUMAN | USP on chromosome 21 | USP21 | USP25 | Ubiquitin carboxyl-terminal hydrolase 25 | Ubiquitin thioesterase 25 | Ubiquitin-specific-processing protease 25
Type:
PROTEIN
Mol. Mass.:
122185.70
Organism:
Homo sapiens
Description:
ChEMBL_118220
Residue:
1055
Sequence:
MTVEQNVLQQSAAQKHQQTFLNQLREITGINDTQILQQALKDSNGNLELAVAFLTAKNAKTPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRETGITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFYGRFLAVGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSENSGKSGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIKREEIKRLKDYLTVLQQRLERYLSYGSGPKRFPLVDVLQYALEFASSKPVCTSPVDDIDASSPPSGSIPSQTLPSTTEQQGALSSELPSTSPSSVAAISSRSVIHKPFTQSRIPPDLPMHPAPRHITEEELSVLESCLHRWRTEIENDTRDLQESISRIHRTIELMYSDKSMIQVPYRLHAVLVHEGQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSFGGYRNASAYCLMYINDKAQFLIQEEFNKETGQPLVGIETLPPDLRDFVEEDNQRFEKELEEWDAQLAQKALQEKLLASQKLRESETSVTTAQAAGDPEYLEQPSRSDFSKHLKEETIQIITKASHEHEDKSPETVLQSAIKLEYARLVKLAQEDTPPETDYRLHHVVVYFIQNQAPKKIIEKTLLEQFGDRNLSFDERCHNIMKVAQAKLEMIKPEEVNLEEYEEWHQDYRKFRETTMYLIIGLENFQRESYIDSLLFLICAYQNNKELLSKGLYRGHDEELISHYRRECLLKLNEQAAELFESGEDREVNNGLIIMNEFIVPFLPLLLVDEMEEKDILAVEDMRNRWCSYLGQEMEPHLQEKLTDFLPKLLDCSMEIKSFHEPPKLPSYSTHELCERFARIMLSLSRTPADGR
  
Inhibitor
Name:
BDBM482065
Synonyms:
US10913753, Compound I-132
Type:
Small organic molecule
Emp. Form.:
C22H27N5OS
Mol. Mass.:
409.548
SMILES:
C[C@@H]1CNCCN1c1ccc(CCNC(=O)c2sc3nc(C)ccc3c2N)cc1 |r|
Structure:
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