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Target
Complement factor D
Ligand
BDBM482850
Substrate
n/a
Meas. Tech.
Human Factor D Assay
IC50
>10000±n/a nM
Citation
 Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X; Greenlee, W Amide compounds for treatment of immune and inflammatory disorders US Patent  US10919884 Publication Date 2/16/2021 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM482850
Synonyms:
N5- (cyclopropylsulfonyl)- 1-(2-((2R,4R)- 4-fluoro-2-((R)-1- hydroxy-2-(6- methylpyridin-2-yl) ethyl)pyrrolidin-1- yl)-2-oxoethyl)- 1H-indole-3,5- dicarboxamide | US10919884, Cmp No. 6 | US11649229, Cmp No. 6
Type:
Small organic molecule
Emp. Form.:
C27H30FN5O6S
Mol. Mass.:
571.62
SMILES:
Cc1cccc(CC(O)[C@H]2C[C@@H](F)CN2C(=O)Cn2cc(C(N)=O)c3cc(ccc23)C(=O)NS(=O)(=O)C2CC2)n1 |r|
Structure:
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