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Target
PAS domain-containing serine/threonine-protein kinase [879-1323]
Ligand
BDBM487225
Substrate
n/a
Meas. Tech.
Radiochemical Assay
IC50
<10000±n/a nM
Citation
 McCall, JM; Kelly, RC; Romero, DL Heterocyclic compounds for the inhibition of pask US Patent  US10953012 Publication Date 3/23/2021 
Target
Name:
PAS domain-containing serine/threonine-protein kinase [879-1323]
Synonyms:
KIAA0135 | PAS domain-containing serine/threonine-protein kinase (PASK) (879-1323) | PASK | PASK_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49711.83
Organism:
Homo sapiens (Human)
Description:
aa 879-1323
Residue:
445
Sequence:
MRGAAGLQREIQEGAYSGSCYHRDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAELTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQPVNLADYTWEEVFRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCLHPGDPRLLTS
  
Inhibitor
Name:
BDBM487225
Synonyms:
3-(4-Fluorophenyl)-2-methyl-5-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one | US10953012, Example 77
Type:
Small organic molecule
Emp. Form.:
C18H13FN4O
Mol. Mass.:
320.3204
SMILES:
Cc1nn2c([nH]c(cc2=O)-c2cccnc2)c1-c1ccc(F)cc1
Structure:
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