Reaction Details Report a problem with these data
Target
Glycogen synthase kinase-3 beta [7-25]
Ligand
BDBM7859
Substrate
GSK-3 Peptide Substrate
Meas. Tech.
Kinase Inhibition Assay
pH
7.5±n/a
Temperature
310.15±n/a K
IC50
1500±n/a nM
Citation
 Conde, S; Perez, DI; Martinez, A; Perez, C; Moreno, FJ Thienyl and phenyl alpha-halomethyl ketones: new inhibitors of glycogen synthase kinase (GSK-3 beta) from a library of compound searching. J Med Chem 46:4631-3 (2003) [PubMed]  Article 
Target
Name:
Glycogen synthase kinase-3 beta [7-25]
Synonyms:
G1T8E2_RABIT | GSK-3, beta | GSK3B | Glycogen Synthase Kinase-3, beta
Type:
Enzyme fragment
Mol. Mass.:
1972.14
Organism:
Oryctolagus cuniculus (rabbit)
Description:
Glycogen Synthase Kinase-3 is the beta isoform of the rabbit enzyme produced in E.coli.. Only partial sequence is available.
Residue:
19
Sequence:
TTSFAESCKPVQQPSAFGS
  
Inhibitor
Name:
BDBM7859
Synonyms:
2-chloro-1-[4-(2-chloroacetyl)thiophen-2-yl]ethan-1-one | Chloromethyl Thienyl Ketone deriv. 7
Type:
Small organic molecule
Emp. Form.:
C8H6Cl2O2S
Mol. Mass.:
237.103
SMILES:
ClCC(=O)c1csc(c1)C(=O)CCl
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
GSK-3 Peptide Substrate
Synonyms:
GS-1 Peptide | Phospho-GS2 Substrate Peptide
Type:
Peptide
Mol. Mass.:
3045.17
Organism:
n/a
Description:
n/a
Residue:
27
Sequence:
YRRAAVPPSPSLSRHSSPHQSPEDEEE