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Target
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
Ligand
BDBM501437
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
1.30±n/a nM
Citation
 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgård, M; Rasmussen, LK; Clementson, CM 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors US Patent  US11026923 Publication Date 6/8/2021 
Target
Name:
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
Synonyms:
3',5'-cyclic-AMP phosphodiesterase | 3',5'-cyclic-GMP phosphodiesterase | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C | Cam-PDE 1C | Hcam3 | PDE1C | PDE1C_HUMAN | Phosphodiesterase 1 | Phosphodiesterase 1C | Phosphodiesterase, PDE1/PDE5
Type:
Enzyme
Mol. Mass.:
80778.58
Organism:
Homo sapiens (Human)
Description:
Q14123
Residue:
709
Sequence:
MESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISSSDAKRSGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVHINRERWRAKVPKEEKAKKEAEEKARLAAEEQQKEMEAKSQAEEGASGKAEKKTSGETKNQVNGTRANKSDNPRGKNSKAEKSSGEQQQNGDFKDGKNKTDKKDHSNIGNDSKKTDGTKQRSHGSPAPSTSSTCRLTLPVIKPPLRHFKRPAYASSSYAPSVSKKTDEHPARYKMLDQRIKMKKIQNISHNWNRK
  
Inhibitor
Name:
BDBM501437
Synonyms:
3-methyl-1-[1-methylpropyl]-N-[(2- methyltetrazol-5-yl]methyl]-5-(2-prepoxy-3- pyridyl)pyrazolo[4,3-b]pyridin-7-amine, enantiomer 2 | US11026923, Example 68
Type:
Small organic molecule
Emp. Form.:
C22H32N8O
Mol. Mass.:
424.5425
SMILES:
CCCOc1ncccc1C\C=C(\NCc1nnn(C)n1)c1cc(C)nn1C(C)CC
Structure:
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