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Target
Glutaminase kidney isoform, mitochondrial
Ligand
BDBM50400050
Substrate
n/a
Meas. Tech.
ChEBML_1558520
IC50
371±n/a nM
Citation
 McDermott, LA; Iyer, P; Vernetti, L; Rimer, S; Sun, J; Boby, M; Yang, T; Fioravanti, M; O'Neill, J; Wang, L; Drakes, D; Katt, W; Huang, Q; Cerione, R Design and evaluation of novel glutaminase inhibitors. Bioorg Med Chem 24:1819-39 (2016) [PubMed]  Article 
Target
Name:
Glutaminase kidney isoform, mitochondrial
Synonyms:
Glutaminase 1 | K-glutaminase | L-glutamine amidohydrolase | GLSK_HUMAN | GLS | GLS1 | KIAA0838
Type:
Protein
Mol. Mass.:
73471.89
Organism:
Human
Description:
O94925
Residue:
669
Sequence:
MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGGGGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEGKELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQTVHKNLDGLL
  
Inhibitor
Name:
BDBM50400050
Synonyms:
CHEMBL2177757 | US8604016, 1 | US9938267, Cmpd ID 1 | US10793535, Cmpd ID 1 | US11191732, Example BPTES
Type:
Small organic molecule
Emp. Form.:
C24H24N6O2S3
Mol. Mass.:
n/a
SMILES:
c1ccc(cc1)CC(=O)Nc2nnc(s2)CCSCCc3nnc(s3)NC(=O)Cc4ccccc4
Structure:
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