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Target
Ephrin type-B receptor 4
Ligand
BDBM50553181
Substrate
n/a
Meas. Tech.
ChEMBL_2045340 (CHEMBL4700039)
EC50
1100±n/a nM
Citation
 Unzue, A; Jessen-Trefzer, C; Spiliotopoulos, D; Gaudio, E; Tarantelli, C; Dong, J; Zhao, H; Pachmayr, J; Zahler, S; Bernasconi, E; Sartori, G; Cascione, L; Bertoni, F; Śledź, P; Caflisch, A; Nevado, C Understanding the mechanism of action of pyrrolo[3,2- RSC Med Chem 11:665-675 (2020) [PubMed]  Article 
Target
Name:
Ephrin type-B receptor 4
Synonyms:
Tyrosine-protein kinase TYRO11 | Ephrin type-B receptor 4 precursor (Tyrosine-protein kinase receptor HTK). | Hepatoma transmembrane kinase | EPHB4_HUMAN | EPHB4 | HTK | MYK1 | TYRO11 | VHL/Ephrin type-B receptor 4 | Ephrin receptor
Type:
Enzyme
Mol. Mass.:
108273.51
Organism:
Human
Description:
P54760
Residue:
987
Sequence:
MELRVLLCWASLAAALEETLLNTKLETADLKWVTFPQVDGQWEELSGLDEEQHSVRTYEVCDVQRAPGQAHWLRTGWVPRRGAVHVYATLRFTMLECLSLPRAGRSCKETFTVFYYESDADTATALTPAWMENPYIKVDTVAAEHLTRKRPGAEATGKVNVKTLRLGPLSKAGFYLAFQDQGACMALLSLHLFYKKCAQLTVNLTRFPETVPRELVVPVAGSCVVDAVPAPGPSPSLYCREDGQWAEQPVTGCSCAPGFEAAEGNTKCRACAQGTFKPLSGEGSCQPCPANSHSNTIGSAVCQCRVGYFRARTDPRGAPCTTPPSAPRSVVSRLNGSSLHLEWSAPLESGGREDLTYALRCRECRPGGSCAPCGGDLTFDPGPRDLVEPWVVVRGLRPDFTYTFEVTALNGVSSLATGPVPFEPVNVTTDREVPPAVSDIRVTRSSPSSLSLAWAVPRAPSGAVLDYEVKYHEKGAEGPSSVRFLKTSENRAELRGLKRGASYLVQVRARSEAGYGPFGQEHHSQTQLDESEGWREQLALIAGTAVVGVVLVLVVIVVAVLCLRKQSNGREAEYSDKHGQYLIGHGTKVYIDPFTYEDPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPASLKIVARENGGASHPLLDQRQPHYSAFGSVGEWLRAIKMGRYEESFAAAGFGSFELVSQISAEDLLRIGVTLAGHQKKILASVQHMKSQAKPGTPGGTGGPAPQY
  
Inhibitor
Name:
BDBM50553181
Synonyms:
CHEMBL4784484
Type:
Small organic molecule
Emp. Form.:
C34H30N10O2
Mol. Mass.:
610.68
SMILES:
CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-n2c(N)c(C(N)=O)c3nc4ccccc4nc23)n(n1)-c1ccc2ncccc2c1
Structure:
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