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TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM312233(US9604926, Compound AZ-66 | US9724435, Compound AZ...)
Affinity DataKi:  0.310nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataIC50: 0.360nMAssay Description:Compound was tested for antagonistic activity against opioid receptor in mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2018
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM312168(US9604926, Compound CM-172 | US9724435, Compound C...)
Affinity DataKi:  0.580nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM312167(US9604926, Compound CM-171 | US9724435, Compound C...)
Affinity DataKi:  0.940nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002254(CHEMBL342267 | 2-(1-Benzyl-piperidin-4-yl)-1-(4-fl...)
Affinity DataKi:  1nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50374598(CHEMBL272603 | US9604926, Compound CM-156 | US9724...)
Affinity DataKi:  1.28nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM312174(US9604926, Compound CM-176 | US9724435, Compound C...)
Affinity DataKi:  1.43nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50017233(LEVO-DROMORAN | CHEMBL592 | LEVORPHANOL)
Affinity DataKi:  1.90nMAssay Description:Binding affinity for mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002303(CHEMBL538532 | 1-Cyclopropylmethyl-4-(3,4-difluoro...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002275(CHEMBL136642 | 1-Benzyl-4-(3-phenyl-propoxy)-piper...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002252(CHEMBL539358 | 1-Benzyl-4-(4-fluoro-phenoxymethyl)...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002190(CHEMBL136495 | 1-Benzyl-4-(4-fluoro-benzyloxymethy...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002241(CHEMBL539567 | 1-(4-Chloro-benzyl)-4-(4-fluoro-ben...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002292(CHEMBL134684 | 4-[4-(4-Fluoro-benzyloxymethyl)-pip...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002207(CHEMBL335327 | 1-Cyclopropylmethyl-4-(4-fluoro-phe...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002219(CHEMBL344422 | 1-Benzyl-4-cyclopropoxymethyl-piper...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002209(CHEMBL136615 | 1-(2,2-Dichloro-1-methyl-cyclopropy...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002235(CHEMBL137768 | 1-Benzyl-4-(4-trifluoromethyl-pheno...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002232(CHEMBL554678 | 1-Benzyl-4-(4-phenyl-butoxymethyl)-...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002229(CHEMBL544847 | 1-Benzyl-4-cyclohexyloxymethyl-pipe...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM312234(US9604926, Compound AZ-68 | US9724435, Compound AZ...)
Affinity DataKi:  2.01nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM312227(US9604926, Compound SC-6 | US9724435, Compound SC-...)
Affinity DataKi:  2.15nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM312154(US9604926, Compound CM-146 | US9724435, Compound C...)
Affinity DataKi:  2.18nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50017232(CHEMBL71301 | 3-Cyclopropylmethyl-5-ethyl-8-hydrox...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity for mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM312178(US9604926, Compound CM-181 | US9724435, Compound C...)
Affinity DataKi:  2.36nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM312161(US9604926, Compound CM-165 | US9724435, Compound C...)
Affinity DataKi:  2.40nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

LigandPNGBDBM50369571(CHEMBL1790710)
Affinity DataIC50: 2.70nMAssay Description:Opioid receptor activity was evaluated using mouse vas deferens (MVD) assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50001683(CHEMBL294616 | 13-[2-Amino-3-(4-hydroxy-phenyl)-pr...)
Affinity DataIC50: 2.80nMAssay Description:Compound was tested for agonistic activity against the opioid receptor in electrically stimulated mouse vas deference.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM312203(US9604926, Compound CM-401 | US9724435, Compound C...)
Affinity DataKi:  2.89nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM15581(US8633208, Clorgyline | [3-(2,4-dichlorophenoxy)pr...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of radioligand binding to sigma1 receptor in C57BL/6 mouse brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002280(CHEMBL442965 | 1-(1-Benzyl-piperidin-4-yl)-2-(4-fl...)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002284(CHEMBL137159 | 1-Benzyl-4-(4-methoxy-phenoxymethyl...)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002263(CHEMBL542737 | 1-Cyclohexylmethyl-4-(4-fluoro-benz...)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002272(CHEMBL423353 | 1-(2-Cyclopropyl-ethyl)-4-(4-fluoro...)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002187(CHEMBL545546 | 1-(1-Benzyl-piperidin-4-yl)-2-(4-fl...)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002217(CHEMBL136768 | 2-[1-(4-Fluoro-benzyl)-piperidin-4-...)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002250(CHEMBL138281 | 1-(4-Fluoro-phenyl)-2-[1-(4-trifluo...)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002197(CHEMBL334466 | 1-(1-Benzyl-piperidin-4-yl)-3-(4-fl...)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM312162(US9604926, Compound CM-166 | US9724435, Compound C...)
Affinity DataKi:  3.15nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002268(CHEMBL337810 | CHEMBL80656 | 1-Benzyl-4-(3-phenyl-...)
Affinity DataKi:  3.20nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50353845(CHEMBL1830149 | US9604926, Compound CM-341 | US972...)
Affinity DataKi:  3.28nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM312147(US9604926, Compound SN-72 | US9724435, Compound SN...)
Affinity DataKi:  3.33nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50374601(CHEMBL408003 | US9604926, Compound CM-135 | US9724...)
Affinity DataKi:  3.37nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002267(CHEMBL136429 | 1-Benzyl-4-(4-methoxy-benzyloxymeth...)
Affinity DataKi:  3.5nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002194(CHEMBL136963 | 4-(4-Fluoro-benzyloxymethyl)-1-phen...)
Affinity DataKi:  4nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002256(CHEMBL542740 | 4-(4-Fluoro-benzyloxymethyl)-1-naph...)
Affinity DataKi:  4nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002293(CHEMBL539302 | 4-(4-Chloro-phenoxymethyl)-1-cyclop...)
Affinity DataKi:  4nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002189(CHEMBL134578 | 2-(1-Benzyl-piperidin-4-yl)-1-(4-me...)
Affinity DataKi:  4nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002290(CHEMBL540585 | 1-Benzyl-4-[2-(4-fluoro-phenoxy)-et...)
Affinity DataKi:  4nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50002222(CHEMBL544146 | 1-Benzyl-4-benzyloxymethyl-piperidi...)
Affinity DataKi:  4nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
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