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TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50276884(CHEMBL42707)
Affinity DataIC50: 0.00200nMAssay Description:Displacement of [3H]17beta-estradiol from ER in human MCF7 cells after 18 hrs by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataEC50:  0.00400nMAssay Description:Activation of human ERalpha expressed in human U2-OS cells by luciferase reporter gene assay relative to untreated controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Ohio State University

Curated by ChEMBL
LigandPNGBDBM50471081(CHEMBL1627420)
Affinity DataEC50:  0.00400nMAssay Description:Induction of pS2 mRNA expression in human MCF-7 mammary carcinoma cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM20625(CHEMBL411 | Stilbestrol | 4-[(3E)-4-(4-hydroxyphen...)
Affinity DataEC50:  0.00700nMAssay Description:In vitro agonist effect on estrogen receptor alpha transcriptional activation in MCF-7 cells at 10 pMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataEC50:  0.00700nMAssay Description:Agonist effect on transcriptional activation in MCF-7 cells expressing estrogen receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataEC50:  0.00840nMAssay Description:Agonist activity at human ERalpha in human MCF7 cells assessed as progesterone receptor endogenous genes activation after 24 hrs by qPCRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM731853(3-((1R,3R)-1-(2,6-difluoro-4- (2-(3-(fluoromethyl)...)
Affinity DataEC50:  0.0100nMAssay Description:All of the exemplary Formula I compounds in Tables 1 and 2 were tested for binding to ERa (Estrogen Receptor alpha) and biological activity according...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50523039(CHEMBL4591338)
Affinity DataIC50: 0.0100nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by FITC/Hoechst 33342 staining based immunofluorescence imaging analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataEC50:  0.0100nMAssay Description:Effect on ERalpha in MCF7 cell line transfected with ER responsive luciferase reporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Ohio State University

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataEC50:  0.0100nMAssay Description:Percent agonistic activity for estrogen-induced pS2 expression in MCF-7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Ohio State University

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataIC50: 0.0100nMAssay Description:In vitro inhibition of estrogen-stimulated MCF-7 cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2018
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50590844(CHEMBL5177342)
Affinity DataEC50:  0.0140nMAssay Description:Modulation of ER-alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50503111(CHEMBL4528514 | US11672785, Goodacre Compound 102 ...)
Affinity DataEC50:  0.0140nMAssay Description:All of the exemplary Formula I compounds in Tables 1 and 2 were tested for binding to ERa (Estrogen Receptor alpha) and biological activity according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50121317(1,1-bis(4,4'-hydroxyphenyl)-2-phenylbut-1-ene | 4,...)
Affinity DataEC50:  0.0150nMAssay Description:Agonist activity at ER in human MCF7:WS8 cells assessed as increase in cell growth by measuring DNA level after 7 days by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Ohio State University

Curated by ChEMBL
LigandPNGBDBM50471255(Acolbifene | EM-652 | SCH-57068)
Affinity DataKi:  0.0150nMAssay Description:Apparent binding affinity against estradiol-stimulated T-47D cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Ohio State University

Curated by ChEMBL
LigandPNGBDBM50471254(CHEMBL308234)
Affinity DataKi:  0.0160nMAssay Description:Apparent binding affinity against estradiol-stimulated T-47D cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM732094((R)-3-((1R,3R)-1-(2,6- difluoro-4-((1-(3- fluoropr...)
Affinity DataEC50:  0.0180nMAssay Description:All of the exemplary Formula I compounds in Tables 1 and 2 were tested for binding to ERa (Estrogen Receptor alpha) and biological activity according...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataEC50:  0.0180nMAssay Description:Transcriptional potency (EC50) at Human estrogen receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataEC50:  0.0190nMAssay Description:Transcriptional activation of estrogen receptor alpha in U2OS cell using estrogen-regulated luciferase reporter gene plasmid upon incubation for 20-3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataIC50: 24nM EC50:  0.0200nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM732114((S)-3-((1R,3R)-1-(2,6- difluoro-4-((1-(3- fluoropr...)
Affinity DataEC50:  0.0210nMAssay Description:All of the exemplary Formula I compounds in Tables 1 and 2 were tested for binding to ERa (Estrogen Receptor alpha) and biological activity according...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50572832(CHEMBL4845726 | US20250114338, Example 425)
Affinity DataEC50:  0.0210nMAssay Description:All of the exemplary Formula I compounds in Tables 1 and 2 were tested for binding to ERa (Estrogen Receptor alpha) and biological activity according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetEstrogen receptor beta(Human)
Ohio State University

Curated by ChEMBL
LigandPNGBDBM50471254(CHEMBL308234)
Affinity DataKi:  0.0230nMAssay Description:Stimulation of alkaline phosphatase activity in human endometrial Ishikawa cells with 1 nM E2 estradiolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM732081((R)-3-((1R,3R)-1-(2,6- difluoro-4-((1-(3- fluoropr...)
Affinity DataEC50:  0.0230nMAssay Description:All of the exemplary Formula I compounds in Tables 1 and 2 were tested for binding to ERa (Estrogen Receptor alpha) and biological activity according...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50572831(CHEMBL4877338 | US20250114338, Example 416)
Affinity DataEC50:  0.0240nMAssay Description:All of the exemplary Formula I compounds in Tables 1 and 2 were tested for binding to ERa (Estrogen Receptor alpha) and biological activity according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50542087(CHEMBL4635493 | US11672785, Goodacre Compound 107 ...)
Affinity DataEC50:  0.0240nMAssay Description:All of the exemplary Formula I compounds in Tables 1 and 2 were tested for binding to ERa (Estrogen Receptor alpha) and biological activity according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataEC50:  0.0240nMAssay Description:Agonist activity at human ERalpha expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50532101(CHEMBL4439408)
Affinity DataIC50: 0.0240nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50532101(CHEMBL4439408)
Affinity DataIC50: 0.0240nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM731939(3-fluoro-N-[2-[3- (fluoromethyl)azetidin-1- yl]eth...)
Affinity DataEC50:  0.0250nMAssay Description:All of the exemplary Formula I compounds in Tables 1 and 2 were tested for binding to ERa (Estrogen Receptor alpha) and biological activity according...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM732100((S)-3-((1R,3R)-1-(2,6- difluoro-4-((1-(3- fluoropr...)
Affinity DataEC50:  0.0260nMAssay Description:All of the exemplary Formula I compounds in Tables 1 and 2 were tested for binding to ERa (Estrogen Receptor alpha) and biological activity according...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50542084(CHEMBL4648503 | US20250114338, Example 128)
Affinity DataEC50:  0.0270nMAssay Description:All of the exemplary Formula I compounds in Tables 1 and 2 were tested for binding to ERa (Estrogen Receptor alpha) and biological activity according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50309557(estrogen | CHEMBL592868)
Affinity DataEC50:  0.0280nMAssay Description:Estrogenic activity at ERalpha in human Ishikawa cells assessed as stimulation of alkaline phosphatase activity after 4 days by microplate scanning s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Ohio State University

Curated by ChEMBL
LigandPNGBDBM50471256(CHEMBL291808)
Affinity DataKi:  0.0280nMAssay Description:Apparent binding affinity against estradiol-stimulated T-47D cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM412253(US10399939, Example 132 | (5R,6S)-5-(4-((1-(3- flu...)
Affinity DataEC50:  0.0290nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM368199((S)-2-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)...)
Affinity DataIC50: 0.0300nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM368199((S)-2-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)...)
Affinity DataIC50: 0.0300nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by FITC/Hoechst staining based immunofluorescence imaging analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM368199((S)-2-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)...)
Affinity DataIC50: 0.0300nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by FITC/Hoechst 33342 staining based immunofluorescence imaging analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM19441(Evista | CHEMBL81 | Keoxifene | Raloxifene, 6 | RA...)
Affinity DataKi:  0.0300nMAssay Description:Antagonistic activity against estrogen receptor alpha in presence of 0.1 nM estradiolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50523049(CHEMBL4441471)
Affinity DataIC50: 0.0300nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by FITC/Hoechst 33342 staining based immunofluorescence imaging analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataEC50:  0.0300nMAssay Description:Estrogenic activity at ERalpha in human Ishikawa cells assessed as induction of alkaline phosphatase activity using p-nitrophenol as substrate treate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Ohio State University

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataEC50:  0.0301nMAssay Description:Induction of pS2 Gene expression in human MCF-7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM731759((1R,3R)-1-[4-[1-(3,3- dimethoxypropyl)azetidin-3- ...)
Affinity DataEC50:  0.0310nMAssay Description:All of the exemplary Formula I compounds in Tables 1 and 2 were tested for binding to ERa (Estrogen Receptor alpha) and biological activity according...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50542086(CHEMBL4649161 | US20250114338, Example 101)
Affinity DataIC50: 0.0310nMAssay Description:Induction of ERalpha degradation in human T47D cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM732083((R)-3-((1R,3R)-1-(2,6- difluoro-4-(2-(3- (fluorome...)
Affinity DataEC50:  0.0320nMAssay Description:All of the exemplary Formula I compounds in Tables 1 and 2 were tested for binding to ERa (Estrogen Receptor alpha) and biological activity according...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM732099((R)-3-((1R,3R)-1-(2,6- difluoro-4-((1-(3- fluoropr...)
Affinity DataEC50:  0.0330nMAssay Description:All of the exemplary Formula I compounds in Tables 1 and 2 were tested for binding to ERa (Estrogen Receptor alpha) and biological activity according...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM732023((S)-3-((1R,3R)-1-(2,6- difluoro-4-((2-(3- (fluorom...)
Affinity DataEC50:  0.0330nMAssay Description:All of the exemplary Formula I compounds in Tables 1 and 2 were tested for binding to ERa (Estrogen Receptor alpha) and biological activity according...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50572818(CHEMBL4847664 | US20250114338, Example 154)
Affinity DataEC50:  0.0330nMAssay Description:All of the exemplary Formula I compounds in Tables 1 and 2 were tested for binding to ERa (Estrogen Receptor alpha) and biological activity according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM361453(2,2-difluoro-3- ((1R,3R)-1-(6- fluoro-3-(2- ((3- f...)
Affinity DataIC50: 0.0340nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM412241(US10399939, Example 120 | (5S,6S)-5-(2-fluoro-4- (...)
Affinity DataEC50:  0.0360nMAssay Description:The relative efficacies of Formula I compounds as inhibitors of an enzyme activity (or other biological activity) can be established by determining t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

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