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TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123247((S)-3-{[5-(3-Guanidino-phenyl)-thiophene-2-carbony...)
Affinity DataIC50: 0.000920nMAssay Description:Inhibition of fibrinogen binding to K562 cells expressing integrin alphaV-beta3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464108(CHEMBL4241824)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity to human integrin alphaVbeta6 assessed as dissociation constant up to 48 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464108(CHEMBL4241824)
Affinity DataKd:  0.0158nMAssay Description:Binding affinity to human integrin alphaVbeta6 after 24 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464108(CHEMBL4241824)
Affinity DataKd:  0.0160nMAssay Description:Binding affinity to human integrin alphaVbeta6 after 24 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50199337(CHEMBL3962660 | US10131658, Compound 6)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of integrin alphaVbeta1 (unknown origin)-mediated CHO cell adhesion to fibronectin preincubated for 15 to 30 mins followed by 60 min incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2018
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464104(CHEMBL4244784)
Affinity DataKi:  0.0200nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50199337(CHEMBL3962660 | US10131658, Compound 6)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of integrin alphaVbeta1 (unknown origin)-mediated CHO cell adhesion to fibronectin preincubated for 15 to 30 mins followed by 60 min incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2018
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464110(CHEMBL4238909)
Affinity DataKi:  0.0251nMAssay Description:Binding affinity to human integrin alphaVbeta6 assessed as dissociation constant up to 48 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50372593(CHEMBL410050)
Affinity DataIC50: 0.0300nMAssay Description:Displacement of [125I]echistatin from human integrin alpha-V-beta-3 receptor high affinity state by solid phase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50191290(3-(5-(2-chloro-4,5-dimethoxybenzylidene)-3-methyl-...)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of [125I]echistatin binding to integrin alphaVbeta3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50191290(3-(5-(2-chloro-4,5-dimethoxybenzylidene)-3-methyl-...)
Affinity DataIC50: 0.0300nMAssay Description:Displacement of [125I]echistatin from integrin alphaVbeta3 in human NCI-H1975 cells after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464123(CHEMBL4242263)
Affinity DataKi:  0.0316nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123248((S)-2-Benzenesulfonylamino-3-{[5-(3-guanidinomethy...)
Affinity DataIC50: 0.0330nMAssay Description:Antagonist activity at alphavbeta3 integrin receptor (unknown origin) by cell-based ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464124(CHEMBL4249629)
Affinity DataKi:  0.0398nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464118(CHEMBL4249172)
Affinity DataKi:  0.0398nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464119(CHEMBL4241584)
Affinity DataKi:  0.0398nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464108(CHEMBL4241824)
Affinity DataKi:  0.0398nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464108(CHEMBL4241824)
Affinity DataKi:  0.0398nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50110227(CHEMBL267434 | CHEMBL2332368 | 3-{2-[4-(4-Methyl-p...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of fibronectin binding to recombinant human alphaV-beta6 integrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123251((S)-2-Benzenesulfonylamino-3-{[5-(2-guanidinomethy...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of fibrinogen binding to integrin alphaV-beta3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50110227(CHEMBL267434 | CHEMBL2332368 | 3-{2-[4-(4-Methyl-p...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) by Merck binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50121964(3-(2-{2-Oxo-3-[2-(5,6,7,8-tetrahydro-[1,8]naphthyr...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of Vitronectin receptor, integrin alphaV-beta3 expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50107412(3-(2-{2-Oxo-3-[2-(5,6,7,8-tetrahydro-[1,8]naphthyr...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50390490(CHEMBL2071603)
Affinity DataKi:  0.0430nMAssay Description:Displacement of [125I]-c(RGDyK) from human integrin alphavbeta3 after 16 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464120(CHEMBL4237919)
Affinity DataKi:  0.0501nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50145527((S)-5-{4-[3-(5-Fluoro-1,4,5,6-tetrahydro-pyrimidin...)
Affinity DataIC50: 0.0550nMAssay Description:Inhibitory activity was determined against human vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50145533((S)-2-Benzyloxycarbonylamino-5-oxo-5-{4-[3-(4,5,6,...)
Affinity DataIC50: 0.0560nMAssay Description:Inhibitory activity was determined against human vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50145528((S)-2-Benzyloxycarbonylamino-5-oxo-5-{4-[3-(1,4,5,...)
Affinity DataIC50: 0.0580nMAssay Description:Inhibitory activity was determined against human vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50092511(3-{4-[2-(6-Amino-pyridin-2-yl)-ethyl]-benzoylamino...)
Affinity DataKd:  0.0600nMAssay Description:Dissociation constant of radiolabeled compound binding to alpha-v-beta-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-8(Human)
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50530090(CHEMBL4443665)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of LAP binding to human integrin alphavbeta8 receptor after 1 hr by solid-phase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50199345(CHEMBL3893700 | US10131658, Compound 201)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of integrin alphaVbeta1 (unknown origin)-mediated CHO cell adhesion to fibronectin preincubated for 15 to 30 mins followed by 60 min incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2018
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-8(Human)
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50530090(CHEMBL4443665)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of LAP binding to human integrin alphavbeta8 receptor after 1 hr by solid-phase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50145530((S)-2-Benzyloxycarbonylamino-5-{4-[3-(5-fluoro-1,4...)
Affinity DataIC50: 0.0630nMAssay Description:Inhibitory activity was determined against human vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464100(CHEMBL4243367)
Affinity DataKi:  0.0631nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464097(CHEMBL4237868)
Affinity DataKi:  0.0631nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464113(CHEMBL4239085)
Affinity DataKi:  0.0631nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464110(CHEMBL4238909)
Affinity DataKi:  0.0631nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50199345(CHEMBL3893700 | US10131658, Compound 201)
Affinity DataIC50: 0.0631nMAssay Description:Inhibition of integrin alphaVbeta1 (unknown origin)-mediated CHO cell adhesion to fibronectin preincubated for 15 to 30 mins followed by 60 min incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2018
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50092512(2-Benzenesulfonylamino-3-{4-[2-(5,6,7,8-tetrahydro...)
Affinity DataIC50: 0.0700nMAssay Description:Displacement of [125I]nonpeptide ligand (compound 7) from purified human recombinant alphaV-beta3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50092512(2-Benzenesulfonylamino-3-{4-[2-(5,6,7,8-tetrahydro...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of Vitronectin receptor, integrin alphaV-beta3 expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50153027((S)-3-Pyrimidin-5-yl-9-(5,6,7,8-tetrahydro-[1,8]na...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464112(CHEMBL4248589)
Affinity DataKi:  0.0794nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464115(CHEMBL4247149)
Affinity DataKi:  0.0794nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464098(CHEMBL4242635)
Affinity DataKi:  0.0794nMAssay Description:Binding affinity to alphaVbeta6 (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50372594(CHEMBL437072)
Affinity DataIC50: 0.0800nMAssay Description:Displacement of [125I]echistatin from human integrin alpha-V-beta-3 receptor high affinity state by solid phase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50153031((S)-3-(2-Methyl-pyrimidin-5-yl)-9-(5,6,7,8-tetrahy...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50134778((S)-3-(6-Methoxy-pyridin-3-yl)-3-{2-oxo-3-[3-(5,6,...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of integrin alphaVbeta3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50092511(3-{4-[2-(6-Amino-pyridin-2-yl)-ethyl]-benzoylamino...)
Affinity DataIC50: 0.0800nMAssay Description:Displacement of [125I]nonpeptide ligand (compound 7) from purified human recombinant alphaV-beta3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50092511(3-{4-[2-(6-Amino-pyridin-2-yl)-ethyl]-benzoylamino...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of Vitronectin receptor, integrin alphaV-beta3 expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50134778((S)-3-(6-Methoxy-pyridin-3-yl)-3-{2-oxo-3-[3-(5,6,...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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