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TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50096347(CHEMBL224752)
Affinity DataIC50: 1nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2016
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50061231(2-Amino-5-(N'-propyl-guanidino)-pentanoic acid | C...)
Affinity DataKi:  1.80nMAssay Description:Compound was tested for binding affinity against recombinant inducible nitric oxide synthase (iNOS) from mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50138191(ONO-1714 | (1S,5S,6R,7R)-7-Chloro-5-methyl-2-aza-b...)
Affinity DataIC50: 3nMAssay Description:Inhibition of inducible nitric oxide synthase (iNOS) in miceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50363262(CHEMBL1944717)
Affinity DataIC50: 5nMAssay Description:Inhibition of mouse iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50330882(CHEMBL1277951 | CHEMBL594682 | N1-((3R,4R)-4-((6-a...)
Affinity DataKi:  5nMAssay Description:Inhibition of mouse recombinant iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50055281(2-Ethyl-isothiourea | S-ethyl-iso-thiourea | S-ETH...)
Affinity DataKi:  5.20nMAssay Description:Binding affinity against mouse Inducible nitric oxide synthase (iNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50328814(6-{{(3''R,4''R)-3''-[2''''-(3''''''-Fluorophenethy...)
Affinity DataKi:  7nMAssay Description:Inhibition of mouse recombinant iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50386178(ONO-1714 | CHEMBL1800346)
Affinity DataIC50: 11nMAssay Description:Inhibition of mouse recombinant iNOS activity assessed as conversion of [14C]-L-arginine to [14C]-L-citrulline by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50255365(CHEMBL1277870 | (+/-)-cis-N1-((3S,4S)-4-((6-amino-...)
Affinity DataKi:  14nMAssay Description:Inhibition of mouse recombinant iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50278675(CHEMBL469987 | (+/-)-cis-6-((4-(2-(3-Fluoropheneth...)
Affinity DataKi:  15nMAssay Description:Inhibition of mouse recombinant iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50096337(CHEMBL3577126)
Affinity DataIC50: 16nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2016
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50096335(CHEMBL2064456)
Affinity DataIC50: 18nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2016
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50330883(CHEMBL1277952 | CHEMBL1233715 | N1-((3R,4S)-4-((6-...)
Affinity DataKi:  19nMAssay Description:Inhibition of mouse recombinant iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50116666(CHEMBL76342 | CHEMBL75304 | 4-Methyl-3,6-dihydro-1...)
Affinity DataIC50: 22nMAssay Description:The concentration required for inhibition of Inducible nitric oxide synthase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50096348(2-Cyano-3,12-Dioxooleana-1,9(11)-Dien-28-Oic Acid ...)
Affinity DataIC50: 23nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2016
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50116674(6-Allyl-4-methyl-5,6-dihydro-1H-pyridin-(2Z)-ylide...)
Affinity DataIC50: 25nMAssay Description:The concentration required for inhibition of Inducible nitric oxide synthase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50096338(CHEMBL3577127)
Affinity DataIC50: 29nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2016
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50115777(3-(3-Ethoxy-4,5-dimethoxy-phenyl)-1-(4-fluoro-phen...)
Affinity DataIC50: 30nMAssay Description:Inhibitory concentration required to produce 50% inhibition of the response was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50138189((4S,5R)-5-Methyl-4-propyl-oxazolidin-(2Z)-ylidenea...)
Affinity DataIC50: 41nMAssay Description:Inhibition of inducible nitric oxide synthase (iNOS) in miceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50330875(trans rac-N1-(4-((6-amino-4-methylpyridin-2-yl)met...)
Affinity DataKi:  48nMAssay Description:Inhibition of mouse recombinant iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50350681(CHEMBL1813771)
Affinity DataIC50: 50nMAssay Description:Inhibition of iNOS in mouse RAW264.7 cells assessed as conversion of L-citrulline to L-arginine incubated for 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50138195((4S,5S)-4,5-Diethyl-oxazolidin-(2Z)-ylideneamine |...)
Affinity DataIC50: 56nMAssay Description:Inhibition of inducible nitric oxide synthase (iNOS) in miceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50401339(CHEMBL4161447)
Affinity DataIC50: 58nMAssay Description:Inhibition of recombinant mouse iNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50330897(CHEMBL1278133 | CHEMBL1233765 | 6-(((3R,4S)-4-(2-(...)
Affinity DataKi:  63nMAssay Description:Inhibition of mouse recombinant iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50138201(5-Methyl-oxazolidin-(2Z)-ylideneamine | CHEMBL1074...)
Affinity DataIC50: 74nMAssay Description:Inhibition of inducible nitric oxide synthase (iNOS) in miceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM29234(CHEMBL481815 | aminopyridine-pyrrolidine, 6 | US90...)
Affinity DataKi:  85nMAssay Description:Inhibition of mouse recombinant iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50330873(trans rac-N1-(4-((6-amino-4-methylpyridin-2-yl)met...)
Affinity DataKi:  88nMAssay Description:Inhibition of mouse recombinant iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50350680(CHEMBL1813770)
Affinity DataIC50: 90nMAssay Description:Inhibition of iNOS in mouse RAW264.7 cells assessed as conversion of L-citrulline to L-arginine incubated for 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50116667(4,5,5-Trimethyl-5,6-dihydro-1H-pyridin-(2Z)-yliden...)
Affinity DataIC50: 100nMAssay Description:The concentration required for inhibition of Inducible nitric oxide synthase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50226527(N-[3-(aminomethyl)benzyl]ethanimidamide | N-(3-Ami...)
Affinity DataIC50: 100nMAssay Description:Inhibition of mouse recombinant iNOS using [3H]L-arginine substrate assessed as formation of [3H]L-citruline by liquid scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50350683(CHEMBL1813764)
Affinity DataIC50: 100nMAssay Description:Inhibition of iNOS in mouse RAW264.7 cells assessed as conversion of L-citrulline to L-arginine incubated for 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50116668(4-Methyl-6-propyl-5,6-dihydro-1H-pyridin-(2Z)-ylid...)
Affinity DataIC50: 100nMAssay Description:The concentration required for inhibition of Inducible nitric oxide synthase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50095303(CHEMBL3589092)
Affinity DataIC50: 100nMAssay Description:Inhibition of mouse recombinant iNOS using [3H]L-arginine substrate assessed as formation of [3H]L-citruline by liquid scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50226527(N-[3-(aminomethyl)benzyl]ethanimidamide | N-(3-Ami...)
Affinity DataIC50: 101nMAssay Description:Inhibition of recombinant mouse iNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50330874(trans rac-N1-(4-((6-amino-4-methylpyridin-2-yl)met...)
Affinity DataKi:  119nMAssay Description:Inhibition of mouse recombinant iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50095172(N-(3-Aminomethyl-phenyl)-thiophene-2-carboxamidine...)
Affinity DataKi:  120nMAssay Description:Inhibition against induced Nitric Oxide Synthase(iNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50138190((4S,5S)-5-Methyl-4-propyl-oxazolidin-(2Z)-ylidenea...)
Affinity DataIC50: 120nMAssay Description:Inhibition of inducible nitric oxide synthase (iNOS) in miceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM29241(quinolinone, 12)
Affinity DataEC50:  120nMAssay Description:Inhibition of mouse iNOS expressed in HEK293 cells assessed as inhibition of nitric oxide production after 18 hrs using 2,3-diaminonaphthalene by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50138192((4S,5R)-4-Ethyl-5-methyl-oxazolidin-(2Z)-ylideneam...)
Affinity DataIC50: 120nMAssay Description:Inhibition of inducible nitric oxide synthase (iNOS) in miceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50350684(CHEMBL1813769)
Affinity DataIC50: 120nMAssay Description:Inhibition of iNOS in mouse RAW264.7 cells assessed as conversion of L-citrulline to L-arginine incubated for 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50138194((4S,5S)-5-Ethyl-4-methyl-oxazolidin-(2Z)-ylideneam...)
Affinity DataIC50: 120nMAssay Description:Inhibition of inducible nitric oxide synthase (iNOS) in miceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50138198((4S,5R)-4,5-Diethyl-oxazolidin-(2Z)-ylideneamine |...)
Affinity DataIC50: 130nMAssay Description:Inhibition of inducible nitric oxide synthase (iNOS) in miceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50138184((4S,5R)-4,5-Dimethyl-oxazolidin-(2Z)-ylideneamine ...)
Affinity DataIC50: 150nMAssay Description:Inhibition of inducible nitric oxide synthase (iNOS) in miceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50095181(N-(3-Aminomethyl-phenyl)-furan-2-carboxamidine | C...)
Affinity DataKi:  160nMAssay Description:Inhibition against induced Nitric Oxide Synthase(iNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50096339(CHEMBL3577128)
Affinity DataIC50: 160nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2016
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50138185((4S,5R)-5-Ethyl-4-methyl-oxazolidin-(2Z)-ylideneam...)
Affinity DataIC50: 160nMAssay Description:Inhibition of inducible nitric oxide synthase (iNOS) in miceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50095302(CHEMBL3589091)
Affinity DataIC50: 165nMAssay Description:Inhibition of mouse recombinant iNOS using [3H]L-arginine substrate assessed as formation of [3H]L-citruline by liquid scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50138187((4S,5S)-4-Ethyl-5-methyl-oxazolidin-(2Z)-ylideneam...)
Affinity DataIC50: 170nMAssay Description:Inhibition of inducible nitric oxide synthase (iNOS) in miceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50403157(CHEMBL4171271)
Affinity DataIC50: 170nMAssay Description:Inhibition of recombinant mouse iNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM152698((S)-2-Amino-5-formimidamidopentanoic acid (7))
Affinity DataKi:  180nM IC50: 400nMpH: 7.4Assay Description:The assay mixture contained L-arginine (10 μM), NADPH (100 μM), oxyhemoglobin (0.125 mg/mL), tetrahydrobiopterin (10 μM), and differen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2015
Entry Details Article
PubMed
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